Potential Role of Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) Gene Polymorphism in Patients with Type 2 Diabetes Mellitus

Document Type : Original Article

Authors

Zagazig University

Abstract

Background: Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) is a cellular modulator of oxidative and lipid metabolism. It has a vital role in the regulation of mitochondrial activity. Patients with type 2 diabetes mellitus (T2DM) have mitochondrial abnormality and reduced mitochondrial numbers within the cells of skeletal muscles.
Objective: To evaluate the correlation between PGC-1α gene polymorphism and T2DM in Egyptian patients attending Zagazig University Hospitals.
Patients and Methods: This was a case-control study including 136 participants of both sexes recruited from the Zagazig University Hospitals. The participants were divided into two equal groups: control group with normal individuals and T2DM group with 68 participants in each group.
Results: The incidence of A allele was significantly higher in T2DM group. Also, there were statistically significant elevations in waist hip ratio (WHR) and fasting blood sugar (FBS) among carriers of GA and AA genotypes. However, there was no significant correlation between gene polymorphism and lipid profile in T2DM group. After applying multivariate analysis, A allele carriers and increased values of WHR, FBS, HOMA-IR and low-density lipoprotein-cholesterol (LDL-c) were detected in T2DM.
Conclusion: We concluded that A allele of PGC-1α polymorphism was a possible predictor of T2DM occurrence in Egyptian patients. Additionally, WHR and FBS were significantly higher among carriers of GA and AA genotypes
 

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The Egyptian Journal of Hospital Medicine
Volume 89, Issue 2
October 2022
Pages 6956-6960

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