Zakaria, A., Sayed, S., Aly, M., Hedeba, W. (2019). Macrophage Migration Inhibitory Factor in the Early Diagnosis of Endometriosis and Relationship to the Stage of the Disease. The Egyptian Journal of Hospital Medicine, 74(6), 1428-1432. doi: 10.21608/ejhm.2019.26983
Abdel Monem M. Zakaria; Sameh S. Sayed; Mekky A. Aly; Wael M. Abou Hedeba. "Macrophage Migration Inhibitory Factor in the Early Diagnosis of Endometriosis and Relationship to the Stage of the Disease". The Egyptian Journal of Hospital Medicine, 74, 6, 2019, 1428-1432. doi: 10.21608/ejhm.2019.26983
Zakaria, A., Sayed, S., Aly, M., Hedeba, W. (2019). 'Macrophage Migration Inhibitory Factor in the Early Diagnosis of Endometriosis and Relationship to the Stage of the Disease', The Egyptian Journal of Hospital Medicine, 74(6), pp. 1428-1432. doi: 10.21608/ejhm.2019.26983
Zakaria, A., Sayed, S., Aly, M., Hedeba, W. Macrophage Migration Inhibitory Factor in the Early Diagnosis of Endometriosis and Relationship to the Stage of the Disease. The Egyptian Journal of Hospital Medicine, 2019; 74(6): 1428-1432. doi: 10.21608/ejhm.2019.26983
Macrophage Migration Inhibitory Factor in the Early Diagnosis of Endometriosis and Relationship to the Stage of the Disease
1Department of Obstetrics and Gynecology, Faculty of Medicine - Al Azhar University
2Department of Clinical Pathology Faculty of Medicine - Al Azhar University
Abstract
Background: Endometriosis is a chronic disease affecting women of reproductive age. Adolescent onset of symptoms is common. Macrophage migration inhibitory factor (MIF) is one of non-invasive blood biomarker that was found in endometriosis. Aim of the work: to evaluate the value of macrophage MIF in peripheral blood of women with and without endometriosis as a non-invasive early diagnostic method and correlate its level to the stage of the disease. Patient and methods: This observational case-control study was conducted in El-Hussein Hospital, Al-Azhar University, Cairo and private clinics. The study was approved by the local research ethics committee. During the period from May 2016 till July 2018. Results: Both groups were comparable as regard the incidence of infertility and the presence of chronic pelvic pain. The infertility was equal in both groups; it affected 96% of patients and control groups. The chronic pelvic pain was symmetrically present in both groups; it affected 70% of endometriosis and the control group. The level of MIF was 10.03±1.78 pg/ml in patients with endometriosis and 4.82±1.78 pg/ml in control group with significant P value (P <0.001). In our study, the level of MIF differed according to the stage of endometriosis, in stage I, it was 8.6±0.2 pg/ml, in stage II, it was 10.1±0.1 pg/ml, in stage III, it was 11.3±0.2 pg/ml and in stage IV, it was 14+0.0 pg/ml. Conclusion: MIF factor is a promising marker not only for noninvasive diagnosis of endometriosis but as a target for therapy also
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