Protective Effect of Taurine Against Bisphenol A -Induced Hepatotoxicity in Albino Rats

Document Type : Original Article

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Abstract

Background: Bisphenol A (BPA) is one of the most utilized industrial chemicals worldwide. It is commonly found in a variety of consumer products. Taurine is  a natural product; has been shown to protect cells against the cytotoxic effects and inflammations associated with oxidative stress and provide anti-inflammatory effects.
Objectives: This study was designed to investigate the toxic effects of BPA on the liver and evaluate the possible protective effect of taurine.
Methods: Forty adult male albino rats were divided equally into four groups (10 rats per group). Group I: Rats fed on basal diet and distilled water. Group II: Received taurine orally (100 mg /kg /day). Group III: Rats treated orally with bisphenol (130 mg /kg /day). Group IV received BPA and taurine. After one month, all animals were sacrificed and blood was collected for analysis.
Results: There is increased serum AST& ALT level and histopathological changes in liver. Toxic effects declined markedly with taurine co-administration.
Conclusions: The present study concluded that BPA has many toxic effects on liver, taurine has a potential protective effect against such harmful effects.
 

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The Egyptian Journal of Hospital Medicine
Volume 89, Issue 2
October 2022
Pages 6226-6230

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