Brain Natriuretic Peptide (BNP) Correlates Echo Finding of Hemodynamic Patent Ductus Arteriosus

Hamed, Ahmed Alaa; Elsayed, Lotfy Mohammed; Aboushokka, Rania Diaa Eldin; Abdallah, Hesham Mohamed; Salama, Raafat Hassan; El Gebaly, Sherief M.

doi:10.21608/ejhm.2022.266049

Brain Natriuretic Peptide (BNP) Correlates Echo Finding of Hemodynamic Patent Ductus Arteriosus

Document Type : Original Article

Authors

10.21608/ejhm.2022.266049

Abstract

Background: When Doppler echocardiography is not readily available, a biomarker like NT-pro-Brain Natriuretic Peptide (BNP) can be used to diagnose patent ductus arteriosus (PDA) in premature infants.
Objective: To evaluate the diagnostic accuracy of the cardiac biomarkers BNP for detection of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm newborns and their correlation to echocardiography results.
Patients and Methods: At tertiary care hospital at National Heart Institute, a total of 46 premature neonates (< 34 weeks gestation) or those whose birth weight was less than 1200 g who were admitted to Neonatal Intensive Care Units (NICUs) were included in this cross-sectional study. Patients with PDA were classified as having either hsPDA or non-hsPDA based on a large ductal flow with left to right shunt on colour Doppler echocardiography, and all participating neonates underwent this evaluation between 48- and 72-hours following birth.
Results: Serum brain-type natriuretic peptide was statistically significantly higher in cases with hsPDA. Serum brain-type natriuretic peptide statistically had significant high diagnostic performance in predicting hemodynamically significant patent ductus arteriosus. Serum brain-type natriuretic peptide at cut-off value of ≥108.0 pg/mL, had moderate sensitivity, but high other characteristics in diagnosing hsPDA.
Conclusion: Preterm newborns at risk for poor outcome due to PDA may be identified by serum brain-type natriuretic peptide in combination with echocardiography.

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