Salem, H., Mosa, A., Matar, E., Elsamanoudy, A. (2019). Day 3 embryo Transfer versus Day 5 Embryo Transferversus Day 6 Embryo Transfer in Cases of Intracytoplasmic Sperm Injection. The Egyptian Journal of Hospital Medicine, 74(5), 1128-1136. doi: 10.21608/ejhm.2019.26379
Hossam Eldin H. Salem; Assem A. Mosa; Emad Eldin R. Matar; Ahmed A. Elsamanoudy. "Day 3 embryo Transfer versus Day 5 Embryo Transferversus Day 6 Embryo Transfer in Cases of Intracytoplasmic Sperm Injection". The Egyptian Journal of Hospital Medicine, 74, 5, 2019, 1128-1136. doi: 10.21608/ejhm.2019.26379
Salem, H., Mosa, A., Matar, E., Elsamanoudy, A. (2019). 'Day 3 embryo Transfer versus Day 5 Embryo Transferversus Day 6 Embryo Transfer in Cases of Intracytoplasmic Sperm Injection', The Egyptian Journal of Hospital Medicine, 74(5), pp. 1128-1136. doi: 10.21608/ejhm.2019.26379
Salem, H., Mosa, A., Matar, E., Elsamanoudy, A. Day 3 embryo Transfer versus Day 5 Embryo Transferversus Day 6 Embryo Transfer in Cases of Intracytoplasmic Sperm Injection. The Egyptian Journal of Hospital Medicine, 2019; 74(5): 1128-1136. doi: 10.21608/ejhm.2019.26379
Day 3 embryo Transfer versus Day 5 Embryo Transferversus Day 6 Embryo Transfer in Cases of Intracytoplasmic Sperm Injection
1Department of Obstetrics and Gynecology, Al-Azhar University
2Department of Pathology, Faculty of Medicine, Al-Azhar University
3Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University
Abstract
Background: IVF is becoming now the gold standard for solving the problem of infertility, nearly million IVF babies were born. The time of embryo transfer still rises a big question and is still a field of great debate whether to transfer it early as day 3 or wait till day 5 or day 6 to give a good chance for embryo selection. Aim of the work: to determine whether embryo transfer on day 3 versus day 5 versus day 6 shows a significant difference in implantation, clinical pregnancy, live birth, miscarriage and multiple pregnancy rates among women undergoing intracytoplasmic sperm injection. Results: Concerning multiple pregnancy rates day 3 embryo transfer was 7 (14%) in compared to 31 (31%) in day 5 embryo transfer in compared to 13 (26%) in day 6 embryo transfer which still shows significant difference between three groups. There was only slight difference between live birth in three groups, for day 3 we had (14%) 19 (5 twins and 9 single) living babies while for day 5 we had (44%) 70 (26 twins and 18 single) while for day 6 we had (20%) 31 (11 twins and 9 single). Using Pearson Chi-Square there was significant difference between the three groups regarding live birth. There was great difference in success rates and outcome of embryo transfer between three groups.Conclusion: From this study we can conclude that there is significant difference in either pregnancy or delivery rates between day 3 and day 5 and day 6 when patients are appropriately randomized. Delaying embryo transfer to day 5 or day 6 offers advantage to patients undergoing ICSI. Embryos that develop to the expanded blastocyst stage and are transferred on day 5 after retrieval are approximately as likely to implant compared to those for which expansion and transfer are delayed until day 6.
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