Circulating Dickkopf-1 as a Biomarker in Neonates with Hypoxic Ischemic Encephalopathy (HIE)

Document Type : Original Article

Authors

25 Elheikh Abdelaal El Marg- Cairo, Egypt

Abstract

Background: The brain damage caused by perinatal hypoxic-ischemic encephalopathy (HIE) can have fatal implications for the baby. Wingless-related integration site (Wnt) signalling is crucial for embryonic cell proliferation, fate determination, and patterning, as Dickkopf-1 (DKK-1) is a secreted protein that plays a role in these processes. Objective: To understand the role of Dkk-1 in the prognosis of newborns with HIE.
Patients and Methods: From November 2019 to April 2020, at the neonatal intensive care unit (NICU), Menoufia University Hospitals we undertook a case–control research. Two groups of patients: Asphyxiated 15 newborns were included in patient group (Group 1). Group 2: 15 newborns in good health. Blood count, liver and kidney function test, and blood gas analysis were performed. CT or MRI scans were performed. Serum DDK-1 levels at admission and discharge were measured. Results: In newborns with HIE, the DKK1 level was greater than in normal neonates. DKK-1 level correlated positively with degree of HIE. DKK-1 level correlated positively with worse outcome among HIE neonates. Serum - level >27 µg /L with a sensitivity of 100% and a specificity of 100% for prediction of mortality in the studied HIE neonates.
Conclusion: There were association between serum DKK-1 level as diagnostic factor and if an Apgar score was less than 3 at the 5th minute, pH less than 7.0, or base excess (BE) less than 12 in the venous or cord blood of neonates within 60 minutes of delivery, asphyxia was diagnosed as a prognostic factor in neonates having HIE.
 

Keywords

The Egyptian Journal of Hospital Medicine
Volume 89, Issue 1
October 2022
Pages 4660-4667

Files

Share

How to cite

Statistics