El Fekey, S., El-Sharkawy, H., Ahmed, A., Nassar, M., Elgendy, M. (2019). Effect of Intravenous Immunoglobulin in Reducing Bilirubin Levels in Hemolytic Disease of Newborn. The Egyptian Journal of Hospital Medicine, 74(5), 957-968. doi: 10.21608/ejhm.2019.25779
Shaimaa Waheed Ibrahim El Fekey; Hamed Mohammed El-Sharkawy; Aisha Abd-Ellatif Elsaied Ahmed; Mohammed Abd-Ellatif Nassar; Marwa Mohamed Elgendy. "Effect of Intravenous Immunoglobulin in Reducing Bilirubin Levels in Hemolytic Disease of Newborn". The Egyptian Journal of Hospital Medicine, 74, 5, 2019, 957-968. doi: 10.21608/ejhm.2019.25779
El Fekey, S., El-Sharkawy, H., Ahmed, A., Nassar, M., Elgendy, M. (2019). 'Effect of Intravenous Immunoglobulin in Reducing Bilirubin Levels in Hemolytic Disease of Newborn', The Egyptian Journal of Hospital Medicine, 74(5), pp. 957-968. doi: 10.21608/ejhm.2019.25779
El Fekey, S., El-Sharkawy, H., Ahmed, A., Nassar, M., Elgendy, M. Effect of Intravenous Immunoglobulin in Reducing Bilirubin Levels in Hemolytic Disease of Newborn. The Egyptian Journal of Hospital Medicine, 2019; 74(5): 957-968. doi: 10.21608/ejhm.2019.25779
Effect of Intravenous Immunoglobulin in Reducing Bilirubin Levels in Hemolytic Disease of Newborn
1Departments of Pediatric Medicine, Faculty of Medicine, Tanta University, Egypt
2Departments of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt
Abstract
Background: hemolytic disease of the newborn is an autoimmune haemolytic disease and caused by antibodies produced due to Rh and ABO incompatibilities. Neonatal jaundice is a common clinical problem encountered during the neonatal period. To avoid the associated neurological complications; exchange transfusion and phototherapy have been traditionally used. Aim of the work: was to assess the efficacy of intravenous immunoglobulins in neonates with Rh and/or ABO incompatibility in reducing the duration of phototherapy and the need for exchange transfusion and hospital stay. Subjects and Methods: in this clinical intervention study 40 patients diagnosed with hemolytic disease of newborn were grouped into group A and B. All neonates were treated with standard protocol for phototherapy and exchange transfusion. Group A patients received only phototherapy. Group B patients received intravenous immunoglobulins in a dose of 0.5 gm/kg of body weight single dose and phototherapy. Exchange transfusion was given to the patients of both groups if the bilirubin rose by 0.5 mg/dl per hour. Results: there was a significant decrease of bilirubin level in group B [that received phototherapy plus Intravenous Immunoglobulin (IVIG)] than group A [that received phototherapy only]. Hospital stay and duration of phototherapy decreased in group B than group A. Number of cases exchanged blood in group A was higher than cases of group B. Conclusion: addition of intravenous immunoglobulins for treatment of hemolytic disease of newborn significantly reduces bilirubin levels, duration of phototherapy, need for exchange transfusion and hospital stay.
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