Proenkephalin A119-159 As A Biomarker of Acute Kidney Injury in ICU Patients with Sepsis

Ibrahim, Mohamed E.; Badr, Mohamed Ibrahim Mohamed; Abd El-Hassib, Dalia Mohamed; Mahdey, Ahmed Wageh

doi:10.21608/ejhm.2022.256323

Proenkephalin A119-159 As A Biomarker of Acute Kidney Injury in ICU Patients with Sepsis

Document Type : Original Article

Authors

10.21608/ejhm.2022.256323

Abstract

Background: Sepsis is a potentially fatal illness caused by an unbalanced host response to infection. Sepsis is becoming more common, indicating that it is a main cause of severe disease and fatality globally. Patients with sepsis commonly have simultaneous acute kidney injury (AKI), with rates ranging from 5 to 20% among hospital admissions and increasing to 35-50% among the seriously sick. Because proenkephalin is not bound to proteins in plasma and is only filtrated in the glomerulus, it is a promising biomarker for renal impairment in critically sick patients. Objective: The aim of the current study was to assess Proenkephalin A119-159 (penKid) as a biomarker for sepsis related AKI in ICU patients. Patients and methods: A case control study was conducted at intensive care unit (ICU) department, Benha Faculty of Medicine on a total of 80 subjects which were divided into 50 septic AKI cases and 30 matched age and sex controls. Subjects met two or more SIRS-criteria and their estimated glomerular filtration rate (eGFR) was determined by the formula derived from the Modification of Diet in Renal Disease (MDRD) Study and the Proenkephalin A119-159 (penkid) was measured by ELISA. Results: The current study demonstrated that, septic AKI cases demonstrated significant increase in penkid compared to control group(p < strong><0.001) and Penkid level showed significantly positive correlation with baseline, after 48 h creatinine, CRP, SIRS and SOFA scores. Penkid was better than creatinine, eGFR and CRP for prediction of non-recovery septic AKI. Conclusion: PenKid was demonstrated to be a reliable surrogate promising biomarker for sepsis related AKI among unselected patients with sepsis. Additionally, penkid demonstrated superior advantage over creatinine, eGFR and CRP in terms of non-recovery septic AKI prediction.

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