Abd-Elaal, H., Kassab, F., Deif, O., Mira, I., Essawy, M. (2019). Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF. The Egyptian Journal of Hospital Medicine, 74(4), 858-866. doi: 10.21608/ejhm.2019.25265
Hany Maged Abd-Elaal; Farid Ahmed Kassab; Osama Deif; Ismael Abd-Elazeem Mira; Mohamed Mohamed Mohamed Essawy. "Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF". The Egyptian Journal of Hospital Medicine, 74, 4, 2019, 858-866. doi: 10.21608/ejhm.2019.25265
Abd-Elaal, H., Kassab, F., Deif, O., Mira, I., Essawy, M. (2019). 'Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF', The Egyptian Journal of Hospital Medicine, 74(4), pp. 858-866. doi: 10.21608/ejhm.2019.25265
Abd-Elaal, H., Kassab, F., Deif, O., Mira, I., Essawy, M. Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF. The Egyptian Journal of Hospital Medicine, 2019; 74(4): 858-866. doi: 10.21608/ejhm.2019.25265
Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF
1Obstetrics and Gynecology department, Faculty of Medicine, Al-Azhar University
2Obstetrics and Gynecology Department, Beni-Suef General Hospital, Ministry of Health, Egypt.
Abstract
The objective of the present study was to compare and evaluate the effectiveness and safety of GnRH agonist long protocol compared with the GnRH antagonist (fixed and flexible) protocols in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles. This study was carried out on 60 patients with polycystic ovarian disease undergoing ICSI, their age ranged from (20 to 40 years). The cases were selected from The International Center for Population Study and Research (ICPS), Al-Azhar University. Eligible patients who accepted to take part in the study were randomized into 3 study group: Group A: 20 patients were included in agonist protocol, Group B: 20 patients were included in fixed antagonist protocol and Group C: 20 patients were included in flexible antagonist protocol. The results obtained from this study indicated no statistically significant differences regarding the pregnancy rates or regarding the developing of ovarian hyperstimulation syndrome (OHSS) complication in the studied population; so larger studies with larger sample size and longer duration are needed to clarify the roles of different IVF protocols.
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