Interleukin-17 Serum Level and Its Prognostic Significance in Children with Immune Thrombocytopenia

Authors

1 Departments of 1Pediatrics

2 2Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Abstract

Background: Immune thrombocytopenia (ITP) is an acquired hematological disorder that is developed secondary to the production of auto-antibodies against platelets leading to isolated thrombocytopenia, in the absence of other causes of thrombocytopenia such as drugs, infections, malignancy, or other autoimmune diseases.
Objective: This study aimed to determine serum levels of IL-17 and evaluate its prognostic significance in children with immune thrombocytopenia.
Subjects and methods: A case control study carried out in Pediatric Hematology Outpatient Clinic, Zagazig University Hospitals during the period from September 2019 to August 2020. It included 100 subjects who were divided into 2 group; 50 children with ITP and 50 age and sex matched healthy children as a control group.
Results: In this study, newly diagnosed patients with ITP had significantly higher levels of IL-17 compared to persistent and chronic patients with ITP (554.3, 259.9 and 158.6 pg/ml in in newly diagnosed ITP, persistent ITP and chronic ITP respectively, p < 0.001).
Conclusion: We concluded that serum IL-17 predicts susceptibility to ITP in Egyptian children with ITP.
The Egyptian Journal of Hospital Medicine
Volume 88, Issue 1
July 2022
Pages 3733-3736

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