Ahmed, A., Ahmed, F., Aldrhopy, A., Ahmed, A. (2022). Intranasal Dexmedetomidine Versus Midazolam as Sedative Premedication for Children in Day Case Surgery. The Egyptian Journal of Hospital Medicine, 88(1), 3722-3726. doi: 10.21608/ejhm.2022.251654
Ashraf Saed Sayed Ahmed; Farahat Ibrahim Ahmed; Ayoub Alhady Ramdan Aldrhopy; Amany Fouad Ahmed. "Intranasal Dexmedetomidine Versus Midazolam as Sedative Premedication for Children in Day Case Surgery". The Egyptian Journal of Hospital Medicine, 88, 1, 2022, 3722-3726. doi: 10.21608/ejhm.2022.251654
Ahmed, A., Ahmed, F., Aldrhopy, A., Ahmed, A. (2022). 'Intranasal Dexmedetomidine Versus Midazolam as Sedative Premedication for Children in Day Case Surgery', The Egyptian Journal of Hospital Medicine, 88(1), pp. 3722-3726. doi: 10.21608/ejhm.2022.251654
Ahmed, A., Ahmed, F., Aldrhopy, A., Ahmed, A. Intranasal Dexmedetomidine Versus Midazolam as Sedative Premedication for Children in Day Case Surgery. The Egyptian Journal of Hospital Medicine, 2022; 88(1): 3722-3726. doi: 10.21608/ejhm.2022.251654
Intranasal Dexmedetomidine Versus Midazolam as Sedative Premedication for Children in Day Case Surgery
Department of Anesthesia, Intensive Care and pain management, Faculty of Medicine Zagazig University, Egypt
Abstract
Background: Anxiety in children undergoing surgery was considered challenging situation for anesthesia. The intranasal dexmedetomidine and intranasal midazolam as preoperative sedation drugs are used. Objective: The aim of the current work was to evaluate and compare intranasal dexmedetomidine versus midazolam as premedication in pediatric anesthesia according to sedation scale, anxiety scale, child - parent separation scale, and mask accepting scale, heart rate, blood pressure, oxygen saturation and respiratory rate. Patients and methods: The study was carried out on 90 children, 2 to 6 years old, who underwnt day surgical procedures at Zagazig Univerisity Hospital. They were randomly assigned into three equal groups, all were given the study drug intranasally diluted in 1 ml NS. C-Group given 1 ml NS, D-group given 2ug/kg dexmedetomidine, and M-group given 0.3mg/kg midazolam. The groups were compared rgarding onset and degree of sedation, child parent separation scale, mask acceptance scale, hemodynamic parameters, and postoperative analgesic requirements. Results: The three groups were comparable with respect to basic demographic data. D - group showed higher alert sedation scale compared to M - group and C - group from 10 min intraoperative. Anxiety scale was significantly higher in C - group in comparison to other groups from 20 min intraoperative. Child parent separation scale was significantly lower in M - group in comparison to M - group and C - group. The median mask acceptance scale was significantly lower in D - group in comparison to M - group and C group. Conclusions: Intranasal dexmedetomidine 2 μg/kg could be used effectively and safely as a pre-anesthetic medication in children undergoing day case surgery compared to Intranasal midazolam 0.3 mg/kg.
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