Ramadan, A., Azab, M., Abdelmaksoud, A., Mohammad, E., Amin, N., Allam, A., Eldsouky, S., Shahat, A. (2022). Serum Levels of Intercellular Adhesion Molecule-1 and TNF- in Patients with COVID-19 and Its Relation to Disease Severity. The Egyptian Journal of Hospital Medicine, 88(1), 3426-3432. doi: 10.21608/ejhm.2022.248721
Amira E. Ramadan; Marwa S. Azab; Abeer E. Abdelmaksoud; Etemad A. Mohammad; Nashwa A. Amin; Amira H. Allam; Samah M. Eldsouky; Amany K. Shahat. "Serum Levels of Intercellular Adhesion Molecule-1 and TNF- in Patients with COVID-19 and Its Relation to Disease Severity". The Egyptian Journal of Hospital Medicine, 88, 1, 2022, 3426-3432. doi: 10.21608/ejhm.2022.248721
Ramadan, A., Azab, M., Abdelmaksoud, A., Mohammad, E., Amin, N., Allam, A., Eldsouky, S., Shahat, A. (2022). 'Serum Levels of Intercellular Adhesion Molecule-1 and TNF- in Patients with COVID-19 and Its Relation to Disease Severity', The Egyptian Journal of Hospital Medicine, 88(1), pp. 3426-3432. doi: 10.21608/ejhm.2022.248721
Ramadan, A., Azab, M., Abdelmaksoud, A., Mohammad, E., Amin, N., Allam, A., Eldsouky, S., Shahat, A. Serum Levels of Intercellular Adhesion Molecule-1 and TNF- in Patients with COVID-19 and Its Relation to Disease Severity. The Egyptian Journal of Hospital Medicine, 2022; 88(1): 3426-3432. doi: 10.21608/ejhm.2022.248721
Serum Levels of Intercellular Adhesion Molecule-1 and TNF- in Patients with COVID-19 and Its Relation to Disease Severity
1Departments of 1Medical Microbiology and Immunology
22Community Medicine
33Chest Diseases
44Otolaryngology, Faculty of Medicine, Benha University, Egypt
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a major health concern and can be devastating, especially for the elderly. It causes a systemic inflammatory response, involving dysregulation and misexpression of many inflammatory cytokines. Objectives: To assess the cytokine profile in COVID-19 patients and detect its relation with disease severity. Patients and methods: This study included 50 COVID-19 patients confirmed by reverse transcription–polymerase chain reaction (RT-PCR), of whom 20 with severe pneumonia, 20 with moderate and 10 with mild disease, and 50 healthy control. Quantitative ELISA tests were performed for tumour necrosis factor alfa (TNF-α) and intercellular adhesion molecule1 (ICAM-1). Results: Level of ICAM-1 is higher in cases of COVID-19 than healthy controls (median for cases = 420 ng/ml). Also TNF-α level is higher in cases with a median of 165 both levels were higher in CORADS 6 and positively correlated with CT findings. Conclusion: Patients with severe COVID-19 might have a cytokine storm syndrome and increased expression of endothelial cell adhesion molecules as ICAM-1, which is related to COVID-19 and disease severity and may contribute to coagulation dysfunction. Levels of ICAM 1 were associated with more severe CT findings and longer hospital stay, also ICAM 1 and TNF can be used as diagnostic measures as they have a higher sensitivity specificity and predictive values.
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