Nasr, Y., Waly, S., Mokhtar, W. (2022). Intraperitoneal Bupivacaine with Dexamethasone versus Bupivacaine Alone for Pain Relief after Laparoscopic Bariatric Surgeries: A Randomized Controlled Trial. The Egyptian Journal of Hospital Medicine, 88(1), 3185-3191. doi: 10.21608/ejhm.2022.246927
Yasser M. Nasr; Salwa H. Waly; Wael Elsayed Lotfy Mokhtar. "Intraperitoneal Bupivacaine with Dexamethasone versus Bupivacaine Alone for Pain Relief after Laparoscopic Bariatric Surgeries: A Randomized Controlled Trial". The Egyptian Journal of Hospital Medicine, 88, 1, 2022, 3185-3191. doi: 10.21608/ejhm.2022.246927
Nasr, Y., Waly, S., Mokhtar, W. (2022). 'Intraperitoneal Bupivacaine with Dexamethasone versus Bupivacaine Alone for Pain Relief after Laparoscopic Bariatric Surgeries: A Randomized Controlled Trial', The Egyptian Journal of Hospital Medicine, 88(1), pp. 3185-3191. doi: 10.21608/ejhm.2022.246927
Nasr, Y., Waly, S., Mokhtar, W. Intraperitoneal Bupivacaine with Dexamethasone versus Bupivacaine Alone for Pain Relief after Laparoscopic Bariatric Surgeries: A Randomized Controlled Trial. The Egyptian Journal of Hospital Medicine, 2022; 88(1): 3185-3191. doi: 10.21608/ejhm.2022.246927
Intraperitoneal Bupivacaine with Dexamethasone versus Bupivacaine Alone for Pain Relief after Laparoscopic Bariatric Surgeries: A Randomized Controlled Trial
Background: Pain after laparoscopic bariatric surgeries has negative effects on patients' recovery. Objective: To evaluate efficacy and safety of adding intraperitoneal dexamethasone to bupivacaine for postoperative pain relief after laparoscopic bariatric surgeries. Patients and Methods: Sixty patients were randomly allocated into 3 groups as follows:Group B (n=20): bupivacaine 100 ml 0.25% + 5 ml normal saline. Group BD4 (n=20): bupivacaine 100 ml 0.25% + 4 mg dexamethasone (1 ml) + saline 4 ml, and Group BD8: (n=20) bupivacaine 100 ml 0.25% + 8 mg dexamethasone (2 ml) + saline 3 ml. Postoperatively ketorolac IV 30 mg/6 hours + Paracetamol IV 1 g/8 hours were given± nalbuphine. Results:Pain was lower in Group BD8. Sedation was deeper in Group B. Time to first supplementary analgesia was longer in Group BD8 than Groups B or BD4, and longer in Group BD4 compared to Group B. Patients requiring supplementary analgesia were less in Group BD8 than Groups B or BD4. Total postoperative consumption of nalbuphine in the firstpostoperative day (POD 1) was less in Group BD8 than Groups B or BD4, and less in Group BD4 than Group B. Time for independent ambulation was shorter in Group BD8 than Groups B or BD4, and shorter in Group BD4 than Group B. Postoperative nausea and vomiting (PONV) was higher in Group B compared to other groups. Conclusion: Intraperitoneal administration of either 4 mg or 8 mg dexamethasone to bupivacaine (0.25%) resulted in better recovery and pain relief after bariatric surgeries. Dexamethasone 8 mg is superior to 4 mg.
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