Mansour, S., Elkanishy, G., Abbas, T., Ibrahim, A. (2022). Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level. The Egyptian Journal of Hospital Medicine, 88(1), 3078-3082. doi: 10.21608/ejhm.2022.244544
Sherif El Sayed Mansour; Ghada Mohamed Hasan Elkanishy; Tarek Medhat Abbas; Ahmed Bahy Eldeen Ibrahim. "Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level". The Egyptian Journal of Hospital Medicine, 88, 1, 2022, 3078-3082. doi: 10.21608/ejhm.2022.244544
Mansour, S., Elkanishy, G., Abbas, T., Ibrahim, A. (2022). 'Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level', The Egyptian Journal of Hospital Medicine, 88(1), pp. 3078-3082. doi: 10.21608/ejhm.2022.244544
Mansour, S., Elkanishy, G., Abbas, T., Ibrahim, A. Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level. The Egyptian Journal of Hospital Medicine, 2022; 88(1): 3078-3082. doi: 10.21608/ejhm.2022.244544
Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level
Background: Elevated incidence of death in hemodialysis (HD) cases is frequently accompanying with quicker atherosclerosis and increased vascular calcification. Objective: The current study aimed to determine the relation between valvular calcification in HD cases and functional vitamin-K (Vit-K) as presented by serum level of uncarboxylated matrix Gla protein (ucMGP) and 25(OH) vitamin-D (Vit-D) levels. Patients and Methods: This work was conducted over six months and included 90 HD cases and 20 apparently healthy adults with normal kidney function (to establish normal range of ucMGP); age and gender matched to the HD cases. Results: About one-third of the patients (41.1%) had calcifications on the aortic valve, and about one-quarter had calcifications on the mitral valve (27.8%). Non-significant association was noted between MGP and vit-D (P = 0.439). Conclusion: We suggested that the end-stage renal disease (ESRD) in HD is accompanied by a shortage levels of vit-K and vit-D built in present work. The most important result of the present work was the significant difference in MGP between patients and controls, suggesting a correlation between MGP level and aortic valve calcifications.