Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level

Mansour, Sherif El Sayed; Elkanishy, Ghada Mohamed Hasan; Abbas, Tarek Medhat; Ibrahim, Ahmed Bahy Eldeen

doi:10.21608/ejhm.2022.244544

Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level

Document Type : Original Article

Authors

10.21608/ejhm.2022.244544

Abstract

Background: Elevated incidence of death in hemodialysis (HD) cases is frequently accompanying with quicker atherosclerosis and increased vascular calcification.
Objective: The current study aimed to determine the relation between valvular calcification in HD cases and functional vitamin-K (Vit-K) as presented by serum level of uncarboxylated matrix Gla protein (ucMGP) and 25(OH) vitamin-D (Vit-D) levels.
Patients and Methods: This work was conducted over six months and included 90 HD cases and 20 apparently healthy adults with normal kidney function (to establish normal range of ucMGP); age and gender matched to the HD cases.
Results: About one-third of the patients (41.1%) had calcifications on the aortic valve, and about one-quarter had calcifications on the mitral valve (27.8%). Non-significant association was noted between MGP and vit-D (P = 0.439).
Conclusion: We suggested that the end-stage renal disease (ESRD) in HD is accompanied by a shortage levels of vit-K and vit-D built in present work. The most important result of the present work was the significant difference in MGP between patients and controls, suggesting a correlation between MGP level and aortic valve calcifications.

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