Effect of Correction of Metabolic Acidosis on Serum Interleukin 10 Levels in Chronic Hemodialysis Patients

Document Type : Original Article

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Abstract

Background: Metabolic acidosis is a common complication in chronic hemodialysis (HD) patients and can cause loss of lean body mass. Interleukin 10 (IL-10) also is increased in chronic HD patients and has a prognostic value.
Objectives: The aim of this study was to evaluate the effect of correction of metabolic acidosis on serum IL-10 levels in chronic hemodialysis patients.
Patients and Methods: Forty chronic hemodialysis patients with predialysis bicarbonate levels Results: Bicarbonate levels significantly increased at end of study (22.83±0.71 vs 18.85±1.12 mEq/l, p < 0.001). Serum IL-10 levels significantly decreased after correction of metabolic acidosis (19.91±6.68 vs 25.89±10.64 pg/ml, p < 0.001) and the change of IL-10 was significantly correlated with the change in bicarbonate (r = - 0.436, p = 0.005).
Conclusions: Correction of metabolic acidosis in chronic hemodialysis patients was associated with decrease in serum IL-10.
 

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The Egyptian Journal of Hospital Medicine
Volume 88, Issue 1
July 2022
Pages 3029-3032

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