Clinical Outcome of Patients with Newly Diagnosed Multiple Myeloma in Zagazig University Hospitals

Elsheikh, Haitham; Fathy, Ayman; El Sayed, Ahmed Mohamed; Zidan, Nahla I.; Embaby, Ahmed

doi:10.21608/ejhm.2022.232248

Clinical Outcome of Patients with Newly Diagnosed Multiple Myeloma in Zagazig University Hospitals

Document Type : Original Article

Authors

10.21608/ejhm.2022.232248

Abstract

Background: Multiple myeloma (MM) is a clonal neoplastic plasma cell disorder. With availability of immunomodulators and bortezomib, better response rate and survival outcome have been achieved in newly diagnosed multiple myeloma (NDMM) patients.
Objective: To evaluate patients’ response and outcomes to anti-myeloma treatment in a tertiary referral center.
Patients and Methods: From September 2020 to February 2022, at Zagazig University Hospitals, Hematology Unit of Internal Medicine Department, our prospective cohort study was conducted on 36 treatment-naïve patients with NDMM. All patients had received anti-myeloma agents and assessed for response and outcome.
Results: About the performance status (PS), one quarter of the cases had PS 0 (25%), and 55.6% of the cases were PS 1. Majority of cases responded to treatment (91.7%), while only three cases did not respond. Thirty-three cases showed no progression (91.7%) and three cases only showed progression (8.3%). Ten patients underwent autologous stem cell transplantation (ASCT). After a median follow-up period of 12 months (range 4-18 months); the OS rate was 76.8%, and PFS rate, was 90.7%.
Conclusion: This study highlights that by using proper anti-myeloma agents, a reasonable clinical outcome can be achieved in our tertiary center

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