Mohamed, S., Abbas, A., Mostafa, E. (2022). High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women: A Randomized Clinical Trial. The Egyptian Journal of Hospital Medicine, 87(1), 1953-1960. doi: 10.21608/ejhm.2022.231666
Safwat Abdelrady Mohamed; Ahmed Mohamed Abbas; Esraa Gamal Abdelnaser Mostafa. "High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women: A Randomized Clinical Trial". The Egyptian Journal of Hospital Medicine, 87, 1, 2022, 1953-1960. doi: 10.21608/ejhm.2022.231666
Mohamed, S., Abbas, A., Mostafa, E. (2022). 'High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women: A Randomized Clinical Trial', The Egyptian Journal of Hospital Medicine, 87(1), pp. 1953-1960. doi: 10.21608/ejhm.2022.231666
Mohamed, S., Abbas, A., Mostafa, E. High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women: A Randomized Clinical Trial. The Egyptian Journal of Hospital Medicine, 2022; 87(1): 1953-1960. doi: 10.21608/ejhm.2022.231666
High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women: A Randomized Clinical Trial
Buckhound: For augmentation of delayed labour, high- or low-dose oxytocin can be used, but the evidence for promoting high-dose in obese women is weak. In obese women, labour progress is often delayed, leading to a caesarean section despite labour augmentation with synthetic oxytocin. Objecitve: Our study aims to evaluate the effect of high dose oxytocin augmentation in spontaneously labouring obese women. Patients and methods: We included 202 patients who were randomly assigned to two groups in a randomized controlled trial (RCT) study. Patients were divided into two groups: Group I (low dose oxytocin) were given 2 mU/minutes (min) of oxytocin, which was gradually increased by 2 mU/min every 30 minutes until adequate uterine contractions were achieved. Patients in Group II (high dose oxytocin) were given 4 mU/min of oxytocin, which was gradually increased by 4 mU/min every 30 minutes until adequate uterine contractions were achieved. Results: Both management were equally effective in clinical data with no significant difference between the two studied groups (P>0.05). Difference in oxytocin dose, duration of oxytocin, and uterine tachysystole between the two groups was statistically significant. The rates of caesarean section did not differ between groups (8.7% and 8.1%). The rates of instrumental vaginal births were similar. In terms of neonatal outcomes, there were no differences. Conclusion: Except for reducing labour duration, high dose oxytocin had no advantages over low dose oxytocin in labour augmentation. Low-dose oxytocin is less likely to cause uterine hyperstimulation, making it a safer option.