Effect of successive cyclic oral contraceptive pills on pregnancy outcome pretreatment of PCOS patient in ICSI

Younes, Hana Abd El Moneim; Abo Shady, Yousef El Said; Abdel Hakam, Fayza A.; Gomaa, Asmaa Mohamed Awad

doi:10.21608/ejhm.2019.22983

Effect of successive cyclic oral contraceptive pills on pregnancy outcome pretreatment of PCOS patient in ICSI

Document Type : Original Article

Authors

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University

10.21608/ejhm.2019.22983

Abstract

Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that primarily affects women of reproductive age, with prevalence rates ranging from 5% to 10%.
Objective: To evaluate the role of oral contraceptive pills (OCP) pretreatment in the improvement of intra cytoplasmic sperm injection (ICSI) pregnancy outcome, in patient with PCOS.
Methodology:Started with 200 proved PCOS and after exclude of any patient with criteria rather than including criteria, so 60 proved PCOS women undergo ICSI were elected and divided into tow groups 30 patients for each. The 1^st group treated with COC (3-6monthes) before ICSI and the 2^nd group was a control group.
Results: Clinical pregnancy rate as a main outcome was significantly more frequent in the study group than in the control group. The LH mean as a secondary outcome was significantly more decreased in the study group than in the control group and the FSH/LH ratio before and after COC increasing ratio towards normalization.
Conclusion: Successive cyclic oral contraceptive pills for patients with PCOS as a pretreatment in ICSI can increase clinical pregnancy rates as a main outcome, improve the synchronism of follicular development, decrease the LH mean as a secondary outcome. And increase FSH/LH ratio before and after COC towards normalization.

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