The Comparative Preemptive Analgesic Efficacy of Addition of vitamin B Complex to Gabapentin versus Gabapentin alone in Orthopedic Surgery under Spinal Anesthesia
Background: development of new multimodal analgesic regimens have led to substantial improvement in postoperative pain relief. Aim of the work: we designed this study to compare the effect of combined vitamin B complex-gabapentin versus gabapentin alone on postoperative pain in orthopedic surgery under spinal anesthesia. Methods: 80 patients who underwent elective orthopedic surgery under spinal anesthesia were randomized to receive orally 300 mg gabapentin (Group G) or 300 mg of gabapentin plus 2 vitamin B complex (Group GB) tablets 30 minutes before surgery. Postoperative pain intensity and total analgesic consumption during 12 hours after surgery, vomiting, and drowsiness during recovery were assessed. Results: the pain intensity in the gabapentin plus vitamin B complex group was lower than gabapentin group during 12 hours after surgery (p-value <0.001). Meanwhile, the total analgesic consumption in this group was less than gabapentin alone(p-value <0.05). The incidence of vomiting in patients who received combined gabapentin—vitamin B complex group was similar to gabapentin alone (p-value >0.05). Conclusion: the combination of vitamin B complex to gabapentin reduced intensity of postoperative pain and also the total amount of analgesic consumption within the first 12 hours postoperative following orthopedic surgery under spinal anesthesia.
Shabayek, I. A., Abdel-Hamid, S. M., & Elbanna, M. M. A. (2019). The Comparative Preemptive Analgesic Efficacy of Addition of vitamin B Complex to Gabapentin versus Gabapentin alone in Orthopedic Surgery under Spinal Anesthesia. The Egyptian Journal of Hospital Medicine, 74(1), 120-125. doi: 10.21608/ejhm.2019.22640
MLA
Ismael Abdel-Latif Shabayek; Saeed Mostafa Abdel-Hamid; Mohamed Mohsen Abdellatif Elbanna. "The Comparative Preemptive Analgesic Efficacy of Addition of vitamin B Complex to Gabapentin versus Gabapentin alone in Orthopedic Surgery under Spinal Anesthesia", The Egyptian Journal of Hospital Medicine, 74, 1, 2019, 120-125. doi: 10.21608/ejhm.2019.22640
HARVARD
Shabayek, I. A., Abdel-Hamid, S. M., Elbanna, M. M. A. (2019). 'The Comparative Preemptive Analgesic Efficacy of Addition of vitamin B Complex to Gabapentin versus Gabapentin alone in Orthopedic Surgery under Spinal Anesthesia', The Egyptian Journal of Hospital Medicine, 74(1), pp. 120-125. doi: 10.21608/ejhm.2019.22640
VANCOUVER
Shabayek, I. A., Abdel-Hamid, S. M., Elbanna, M. M. A. The Comparative Preemptive Analgesic Efficacy of Addition of vitamin B Complex to Gabapentin versus Gabapentin alone in Orthopedic Surgery under Spinal Anesthesia. The Egyptian Journal of Hospital Medicine, 2019; 74(1): 120-125. doi: 10.21608/ejhm.2019.22640
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