Abdelsalam, H., Gobran, M., Abdelwahab, M., Abdelaziz, H. (2022). A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression. The Egyptian Journal of Hospital Medicine, 86(1), 840-844. doi: 10.21608/ejhm.2022.218029
Hajir Fathalla Farag Abdelsalam; Mai Ahmad Gobran; Mai Mohamed Abdelwahab; Hesham Radwan Abdelaziz. "A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression". The Egyptian Journal of Hospital Medicine, 86, 1, 2022, 840-844. doi: 10.21608/ejhm.2022.218029
Abdelsalam, H., Gobran, M., Abdelwahab, M., Abdelaziz, H. (2022). 'A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression', The Egyptian Journal of Hospital Medicine, 86(1), pp. 840-844. doi: 10.21608/ejhm.2022.218029
Abdelsalam, H., Gobran, M., Abdelwahab, M., Abdelaziz, H. A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression. The Egyptian Journal of Hospital Medicine, 2022; 86(1): 840-844. doi: 10.21608/ejhm.2022.218029
A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression
Introduction: The prototypical psoriasiform tissue pattern is psoriasis, both clinically and histopathologically. However, it should be distinguished from other psoriasiform dermatoses. Objective: This study aimed to determine the expression of Ki-67 immunohistochemically in psoriasis and psoriasiform dermatoses for diagnostic reasons. Material and Methods: Between January 2020 and January 2021, a cross-sectional study was conducted on the paraffin blocks of 22 psoriasis and 22 psoriasiform dermatoses patients. Four-micron sections were cut from formalin-fixed paraffin-embedded tissue from each biopsy specimen. Hematoxylin and eosin staining was used to colour the initial sections. Additionally, Ki-67 immunohistochemistry was performed. Results: Mean value of KI-67 expression was highly significant in psoriasis (94.4 ± 11) versus (21.1 ± 5.7) than in psoriasiform dermatoses (P value < 0.001). Conclusion: Ki-67 expression was shown to be significantly elevated in psoriasis compared to the other types of dermatoses studied.