Polymorphism RS2227306 In The Interleukin 8 Gene and Its Relation to Bronchial Asthma: Review Article

Hafez, Sahbaa Fehr Mohamed; Amer, Osama Taha; Mostafa, Osama Abd Elaziz; Samy, Walaa Mohamed

doi:10.21608/ejhm.2021.209977

Polymorphism RS2227306 In The Interleukin 8 Gene and Its Relation to Bronchial Asthma: Review Article

Document Type : Original Article

Authors

10.21608/ejhm.2021.209977

Abstract

Background: Allergy symptoms such as wheezing, breathlessness, and coughing are all symptoms of asthma, which is a long-term respiratory condition characterized by inflammation and reversible airway blockage. If you're a child or young adult, asthma is the most common long-term condition, with more severe symptoms. The CXC chemokine superfamily includes the Interleukin 8 (IL-8) chemokine. T lymphocytes, neutrophils, and mast cells are all chemotactic cytokines that IL-8 attracts in the body. A polymorphism in the promoter region of IL-8 - 781C/T (rs2227306) has been found to be associated with an elevated level of the cytokine IL-8. There is a gene in the first intron of the IL-8 - 781C/T (rs2227306) that has been reported to aid in both gene transcription and gene regulation.
Objective: The aim of the present review was to study polymorphism RS2227306 in the interleukin 8 gene and its relation to bronchial asthma.
Conclusion: IL8 polymorphism rs2227306 has the potential to be utilized as a marker in interpretation of assessment of severity of asthma.

Keywords