Bazeed, M., Elsheety, A., Bakeer, M., Saber, M., Mohammady, E. (2018). Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients. The Egyptian Journal of Hospital Medicine, 73(10), 7842-7849. doi: 10.21608/ejhm.2018.20458
Mahmoud Mohammad Moussa Bazeed; Anwar Gomaa Elsheety; Mohammad Saied Bakeer; Mohamed Ali Saber; Essam Abdel Nabi Mohammady. "Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients". The Egyptian Journal of Hospital Medicine, 73, 10, 2018, 7842-7849. doi: 10.21608/ejhm.2018.20458
Bazeed, M., Elsheety, A., Bakeer, M., Saber, M., Mohammady, E. (2018). 'Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients', The Egyptian Journal of Hospital Medicine, 73(10), pp. 7842-7849. doi: 10.21608/ejhm.2018.20458
Bazeed, M., Elsheety, A., Bakeer, M., Saber, M., Mohammady, E. Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients. The Egyptian Journal of Hospital Medicine, 2018; 73(10): 7842-7849. doi: 10.21608/ejhm.2018.20458
Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients
Department of Internal Medicine, Faculty of Medicine, Al-Azhar University
Abstract
Introduction: for SNP, the CC is associated with a higher SVR after DAAs/RBV therapy while, the genotype TT is a risk factor for non-response. Aim of the work: this study aimed to assess the value of SNP (rs8o99917) as a predictor of SVR. Methodology: this study was a retrospective controlled study and was performed on a total number of 15o patients who were treated by DAAs/RBV for 12 weeks and SNP was done for the all the patients. Results: CC genotype was more prevalent in SVR group than CT and TT genotypes. Conclusion: determination of SNP before starting antiviral therapy may serve as a good response predictor.
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