Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients

Bazeed, Mahmoud Mohammad Moussa; Elsheety, Anwar Gomaa; Bakeer, Mohammad Saied; Saber, Mohamed Ali; Mohammady, Essam Abdel Nabi

doi:10.21608/ejhm.2018.20458

Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients

Document Type : Original Article

Authors

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University

10.21608/ejhm.2018.20458

Abstract

Introduction: for SNP, the CC is associated with a higher SVR after DAAs/RBV therapy while, the genotype TT is a risk factor for non-response. Aim of the work: this study aimed to assess the value of SNP (rs8o99917) as a predictor of SVR. Methodology: this study was a retrospective controlled study and was performed on a total number of 15o patients who were treated by DAAs/RBV for 12 weeks and SNP was done for the all the patients. Results: CC genotype was more prevalent in SVR group than CT and TT genotypes. Conclusion: determination of SNP before starting antiviral therapy may serve as a good response predictor.

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