Gobran, M., Embaby, A., Hafeez, A. (2021). Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases. The Egyptian Journal of Hospital Medicine, 85(2), 3778-3782. doi: 10.21608/ejhm.2021.204575
Mai Ahmed Gobran; Ahmed Embaby; Abeer Hafeez. "Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases". The Egyptian Journal of Hospital Medicine, 85, 2, 2021, 3778-3782. doi: 10.21608/ejhm.2021.204575
Gobran, M., Embaby, A., Hafeez, A. (2021). 'Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases', The Egyptian Journal of Hospital Medicine, 85(2), pp. 3778-3782. doi: 10.21608/ejhm.2021.204575
Gobran, M., Embaby, A., Hafeez, A. Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases. The Egyptian Journal of Hospital Medicine, 2021; 85(2): 3778-3782. doi: 10.21608/ejhm.2021.204575
Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases
Background: Primary cutaneous lymphoma (PCL) with clonal proliferation of atypical CD4+ skin-homing T lymphocyte cells is called Mycosis Fungoides (MF). TOX staining is observed in subtypes of PCL, as MF & Sézary Syndrome (SS) in comparison to controls. Early MF is difficult to diagnose, & its distinction from inflammatory diseases may be impossible. Objective: This study aimed to evaluate the expression of the TOX versus CD3 as a diagnostic marker for early MF. Patients and methods: retrospective-cross sectional study includes 30 MF and 30 benign cutaneous inflammatory diseases (BCID) cases. All were evaluated using H & E and immunohistochemical staining for TOX & CD3. Results: There was statistically significant increase of TOX & CD3 expression in MF than BCID & ability of TOX to detect all true positive cases (100.0%) compared to (76.7%) for CD3, (P < 0.001). Conclusion: TOX had the highest sensitivity (100.0%) & accuracy (88.3%). TOX is useful marker in the diagnosis of early MF & differentiating it from BCID.