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Mohamed, S., Abd-Elwahab, F., Shokry, D., Samy, W. (2021). Relation between Interleukin 8 and Bronchial Asthma in Children: Review Article. The Egyptian Journal of Hospital Medicine, 85(2), 3621-3623. doi: 10.21608/ejhm.2021.201975
Sahbaa Fehr Mohamed; Fathy Mohamed Abd-Elwahab; Dina Mohamed Shokry; Walaa Mohamed Samy. "Relation between Interleukin 8 and Bronchial Asthma in Children: Review Article". The Egyptian Journal of Hospital Medicine, 85, 2, 2021, 3621-3623. doi: 10.21608/ejhm.2021.201975
Mohamed, S., Abd-Elwahab, F., Shokry, D., Samy, W. (2021). 'Relation between Interleukin 8 and Bronchial Asthma in Children: Review Article', The Egyptian Journal of Hospital Medicine, 85(2), pp. 3621-3623. doi: 10.21608/ejhm.2021.201975
Mohamed, S., Abd-Elwahab, F., Shokry, D., Samy, W. Relation between Interleukin 8 and Bronchial Asthma in Children: Review Article. The Egyptian Journal of Hospital Medicine, 2021; 85(2): 3621-3623. doi: 10.21608/ejhm.2021.201975

Relation between Interleukin 8 and Bronchial Asthma in Children: Review Article

Article 24, Volume 85, Issue 2, October 2021, Page 3621-3623  XML PDF (369.85 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.201975
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Authors
Sahbaa Fehr Mohamed; Fathy Mohamed Abd-Elwahab email ; Dina Mohamed Shokry; Walaa Mohamed Samy
Abstract
Background: Asthma is a frequent respiratory condition to treat. A persistent airway inflammation characterizes this frequent form of pulmonary disease. Immune responses are triggered by cytokines and chemokines produced by airway epithelial cells.  Human bronchial epithelial cells secrete IL-8 in response to the presence of interleukin-4 (IL-4) and interleukin-13, both of which are increased in asthmatics. There are two receptors for IL-8, the IL-8 receptor alpha (also known as CXCR1) and beta (also known as the IL-8 RB, CXCR2). IL8 is a potent chemotactic cytokine that activates inflammatory cells by recruiting mast cells, mononuclear phagocytes T lymphocytes, and neutrophils to the site of inflammation. Objective: To determine the relationship between IL8 and bronchial asthma in children.
Conclusion: The assessment of IL8 levels in pediatric asthmatic patients is a useful biomarker reflecting the status of asthma and also to glucocorticoids and treatment responses.
 
 
Keywords
Bronchial asthma; Interleukin 8
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