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Alaa Nabel El Sadek, A., Nasr, M., Abdo, O., El Aidy, M. (2021). Role of Corticosteroids versus Hyaluronic Acid in Healing of Sciatic Nerve Injury in Male Albino Rats. The Egyptian Journal of Hospital Medicine, 85(2), 3573-3577. doi: 10.21608/ejhm.2021.201961
Alaa Nabel Alaa Nabel El Sadek; Mohamed Ali Nasr; Osama El Sayed Ibrahem Abdo; Mostafa Mohamed El Aidy. "Role of Corticosteroids versus Hyaluronic Acid in Healing of Sciatic Nerve Injury in Male Albino Rats". The Egyptian Journal of Hospital Medicine, 85, 2, 2021, 3573-3577. doi: 10.21608/ejhm.2021.201961
Alaa Nabel El Sadek, A., Nasr, M., Abdo, O., El Aidy, M. (2021). 'Role of Corticosteroids versus Hyaluronic Acid in Healing of Sciatic Nerve Injury in Male Albino Rats', The Egyptian Journal of Hospital Medicine, 85(2), pp. 3573-3577. doi: 10.21608/ejhm.2021.201961
Alaa Nabel El Sadek, A., Nasr, M., Abdo, O., El Aidy, M. Role of Corticosteroids versus Hyaluronic Acid in Healing of Sciatic Nerve Injury in Male Albino Rats. The Egyptian Journal of Hospital Medicine, 2021; 85(2): 3573-3577. doi: 10.21608/ejhm.2021.201961

Role of Corticosteroids versus Hyaluronic Acid in Healing of Sciatic Nerve Injury in Male Albino Rats

Article 16, Volume 85, Issue 2, October 2021, Page 3573-3577  XML PDF (646.81 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.201961
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Authors
Alaa Nabel Alaa Nabel El Sadek; Mohamed Ali Nasr; Osama El Sayed Ibrahem Abdo email ; Mostafa Mohamed El Aidy
Abstract
Background: Peripheral nerve lesions are common and severe injuries that impact about 2.8% of traumatic patients annually, and result in lifetime disability if untreated. Objective: This study aimed to investigate the effect of corticosteroids vs hyaluronic acid in peripheral nerve healing in rats.
Patients and methods: This was experimental and histopathological study that had included (18) Sprague-Dawley rats with an average weight of 300–350 gm. All rats were divided into three groups (n=6 per group). Group 1; Corticosteroids was injected under epineurium after primary repair. Group 2; Hyaluronic acid group: the site of anastomosis was coated by hyaluronic acid after primary repair. Group 3; Primary repair only was done.
Results: 100% of cases in group 1 and group 2 showed satisfactory wound healing and 83.3% in group3 showed satisfactory wound healing with no significant difference between them. Conclusion: There was an increase in the number of regenerated nerve fibers in the corticosteroids and hyaluronic acid especially on the distal end in comparison to the control group.
 
Keywords
Corticosteroids; Hyaluronic acid; Peripheral nerve; Rats
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