Mohammad, M., Nasr, S., Ahmed, A., Eldein, N. (2021). Value of Regulatory T Cell in Hepatocellular Carcinoma Patients. The Egyptian Journal of Hospital Medicine, 85(1), 3228-3235. doi: 10.21608/ejhm.2021.196476
Maher Borai Mohammad; Seham Mahrous Zaki Nasr; Afifi Fahmy Afifi Ahmed; Neveen Emam- Eldein. "Value of Regulatory T Cell in Hepatocellular Carcinoma Patients". The Egyptian Journal of Hospital Medicine, 85, 1, 2021, 3228-3235. doi: 10.21608/ejhm.2021.196476
Mohammad, M., Nasr, S., Ahmed, A., Eldein, N. (2021). 'Value of Regulatory T Cell in Hepatocellular Carcinoma Patients', The Egyptian Journal of Hospital Medicine, 85(1), pp. 3228-3235. doi: 10.21608/ejhm.2021.196476
Mohammad, M., Nasr, S., Ahmed, A., Eldein, N. Value of Regulatory T Cell in Hepatocellular Carcinoma Patients. The Egyptian Journal of Hospital Medicine, 2021; 85(1): 3228-3235. doi: 10.21608/ejhm.2021.196476
Value of Regulatory T Cell in Hepatocellular Carcinoma Patients
Departments of 1Clinical Pathology Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, representing the second leading cause of cancer-related death worldwide. It is the 2nd leading cause of cancer death in men and the sixth among women. Objectives: To investigate the role of CD4+, CD25+, FOXp3+Regulatory T cells (Tregs) in patients with HCC and their correlation with the prognosis. Patients and Methods: The study was conducted on 25 patients with hepatocellular carcinoma. Detection of regulatory T cells by flow cytometry using CD4, CD25 and FOXp3 before and after intervention. Results: CD4 significantly increased but CD4/CD25, Foxp3, AFP, ALT and AST significantly decreased. Patients with high numbers of FOXp3+ cells and those with higher FOXp3+ Tregs /CD4+ T cell ratio had poorer overall survival rates. Conclusion: Tregs seem to be a promising prognostic factor in patients with HCC and a high Tregs level has been reported to be correlated with poor outcomes in a number of publications.