Faraj, M., Abd Elhalim, S., Shokry, D., Hafez, S. (2021). Evaluation of Biochemical Bone Markers in Children with Nephrotic Syndrome with Correlation to Its Severity. The Egyptian Journal of Hospital Medicine, 85(1), 2751-2757. doi: 10.21608/ejhm.2021.189850
Mansour Khamees Faraj; Samar Mahmoud Abd Elhalim; Dina Mohamed Shokry; Sahbaa Fehr Mohamed Hafez. "Evaluation of Biochemical Bone Markers in Children with Nephrotic Syndrome with Correlation to Its Severity". The Egyptian Journal of Hospital Medicine, 85, 1, 2021, 2751-2757. doi: 10.21608/ejhm.2021.189850
Faraj, M., Abd Elhalim, S., Shokry, D., Hafez, S. (2021). 'Evaluation of Biochemical Bone Markers in Children with Nephrotic Syndrome with Correlation to Its Severity', The Egyptian Journal of Hospital Medicine, 85(1), pp. 2751-2757. doi: 10.21608/ejhm.2021.189850
Faraj, M., Abd Elhalim, S., Shokry, D., Hafez, S. Evaluation of Biochemical Bone Markers in Children with Nephrotic Syndrome with Correlation to Its Severity. The Egyptian Journal of Hospital Medicine, 2021; 85(1): 2751-2757. doi: 10.21608/ejhm.2021.189850
Evaluation of Biochemical Bone Markers in Children with Nephrotic Syndrome with Correlation to Its Severity
Background: Vitamin D is a vital component of bone metabolism and calcium homeostasis, and its deficiency is known to cause rickets, osteomalacia and hypocalcemia. Objective: The aim of this study was to evaluate vitamin D level in patients with nephrotic syndrome and its relation to calcium. Patients and methods: This study was a case-control study carried out at Pediatric Nephrology Unit Pediatric Department, Faculty of Medicine, Zagazig University Hospitals from June 2020 to December 2020. It included 108 patients divided into 2 groups; each group included 54 patients.1st group was patients with nephrotic syndrome and 2nd group was healthy children as control group. A detailed history and clinical examination including anthropometry was taken for cases of Nephrotic syndrome admitted to the hospital. The patients underwent the following investigations: serum albumin, serum cholesterol, C3, C4, alkaline phosphatase, total calcium, ionized calcium, 25(OH) vitamin D, CBC, renal function test, urine analysis urine albumin/creatinine ratio, 24hr urine protein and X-ray bone. Results: There was statistically significant relation between vitamin D level and steroid response where steroid-resistant patient had lower vitamin level followed by steroid-dependent then steroid-sensitive patients. There was non-significant correlation between vitamin D and occurrence of relapse. Conclusion: Vitamin D and calcium supplementation should be considered in nephrotic patients.
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