Fluoxetine Hcl Induced Intrauterine Foetal Growth Retardation And Skeletal Malformation In Pregnant Mice

Ali, M.O; Sharf-El Deen, U.A; El Menshawy, O.M; Bakry, S.A.

doi:10.21608/ejhm.2002.18857

Fluoxetine Hcl Induced Intrauterine Foetal Growth Retardation And Skeletal Malformation In Pregnant Mice

Document Type : Original Article

Authors

Zoology Dept. Fac. Sci., Al-Azhar Univ., Nasr city , Cairo, Egypt.

10.21608/ejhm.2002.18857

Abstract

Fluoxetine is antidepressant drug which widely known as Prozac® , is a fluorinated methyl phenoxy derivative of phenylpropylamine. Fluoxetine is a bicyclic antidepressant that differs structurally and pharmacologically from other currently available antidepressant agents. 80 pregnant mice were administrated oral doses of Fluoxetine (0.052, 0.104 & 0.208 mg/mouse /day) From 6th up to both 15th and 19th days of gestation. The pregnant mice treated with Fluoxetine HCl showed states of instability, nervousness, twitching of head, agitation, hazy movement and marked reduction in food intake as well as reduction in the body weight. The results of uteri examination of pregnant mice groups on both 15th and 19th days of gestation showed remarkable reduction in their size, dismorphology, length and number of implantation sites as well as large reduction in the number of still live embryos. Increase in the number of dead and resorbed mouse embryos was dose dependant. Also, the results showed reduction in both body weight and crown rump of mouse embryos. The treated mouse foetuses showed several malformations as diminution in size, exenocephalia and skeletal malformations.

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