Moustafa, S. (2002). Age-related changes in microsome-dependent conversion of T-T, thyroid function and cadmium toxicity in albino rat.. The Egyptian Journal of Hospital Medicine, 7(1), 126-140. doi: 10.21608/ejhm.2002.18845
Sohair A. Moustafa. "Age-related changes in microsome-dependent conversion of T-T, thyroid function and cadmium toxicity in albino rat.". The Egyptian Journal of Hospital Medicine, 7, 1, 2002, 126-140. doi: 10.21608/ejhm.2002.18845
Moustafa, S. (2002). 'Age-related changes in microsome-dependent conversion of T-T, thyroid function and cadmium toxicity in albino rat.', The Egyptian Journal of Hospital Medicine, 7(1), pp. 126-140. doi: 10.21608/ejhm.2002.18845
Moustafa, S. Age-related changes in microsome-dependent conversion of T-T, thyroid function and cadmium toxicity in albino rat.. The Egyptian Journal of Hospital Medicine, 2002; 7(1): 126-140. doi: 10.21608/ejhm.2002.18845
Age-related changes in microsome-dependent conversion of T-T, thyroid function and cadmium toxicity in albino rat.
Department of Zoology, Faculty of Science, Ismailia, Egypt
Abstract
The impact of age on microsomal function, manifested by its ability to convert thyroid hormone thyroxine (T ) to triiodothyronine (T&), was investigated using four age '& ( ) -months). The data show impaired microsomal function with advancing age represented by a significant decrease in serum levels of T& and T&/T ratio. There was a decline in the liver glutathione (GSH), total proteins and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma- glutamyl transpeptidase (*GT). There was an-age associated increase in liver content of the lipid peroxidation products, thiobarituric acid (TBA)-reactants and the serum total protein. ++ , - . '(+ - / ' + -old) +0- 1-) mg/kg CdCl 2their controls were injected with distilled water. A higher susceptibility of senile rats to cadmium toxicity was manifested as a significantly higher decrease in their serum T& level and T&/T ratio than adult compared to control. A reduction in the adaptive response of senile animals was manifested by a less increase in hepatic GSH in senile than adult as compared to control. The level of hepatic TBA-reactants was significantly higher in treated than in control group. The increase was more pronounced in the senile group. A marked hepatic cellular damage indicated by an increase in the serum levels of the AST and ALT was more pronounced in senile compared with adult rats. Treatment resulted in a decrease in the serum *GT and liver triglycerides (TG). The decrease in both parameters was more evident in senile as compared to adult group.
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