Histopathological and Biochemical Evaluation of the Pulmonary Toxicity of Cadmium Chloride and thiocarbamate

Document Type : Original Article

Authors

1 Department of Forensic Medicine and Toxicology, Faculty of Medicine (for Girls) Al AL Azhar University

2 Department of Pathology, Cairo University

3 Department of Biochemistry, Animal Health Research Institute Dokki

Abstract

The aim of the present work is to study the acute pulmonary toxicity of cadmium chloride (CdCl) and diethyldithiocarbamate (DDTC) each separately and in  "#  $     %& '(( )  "%& '**+(),  - #    .    #  $ /! .0  . cadmium content in the blood and lung were measured by atomic absorption spectrophotometer. It was found that the blood cadmium concentration significantly   '12!),.  . "      
However, with combined treatment the cadmium level in the lung showed significant
  '1 2 !)  /   0    , #             !
Histopathological examination of the lung showed inflammatory infiltrate of alveolar septa specially around blood vessels in DDTC treated animals. While that were exposed to CdCl and to combined (CdCl + DDTC) showed interstitial fibrosis and chronic inflammation. These changes were more severe and serious with combined exposure. Moreover the electr  "   0"       !  of combined exposure showed damage of type I pneumocytes, hyperplasia of type II pneumocytes with loss of microvilli. While the interstitial tissue revealed collagen bundle and chronic inflammatory cells.

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