Shata, M., Shatla, H., Badawy, S., Metkees, M. (2021). Effects of Levetiracetam and Topiramate Monotherapy on Oral Health in Epileptic Children. The Egyptian Journal of Hospital Medicine, 84(1), 2411-2416. doi: 10.21608/ejhm.2021.184657
Mennatallah O. Shata; Hamed M Shatla; Sherine Badawy; Mostafa M Metkees. "Effects of Levetiracetam and Topiramate Monotherapy on Oral Health in Epileptic Children". The Egyptian Journal of Hospital Medicine, 84, 1, 2021, 2411-2416. doi: 10.21608/ejhm.2021.184657
Shata, M., Shatla, H., Badawy, S., Metkees, M. (2021). 'Effects of Levetiracetam and Topiramate Monotherapy on Oral Health in Epileptic Children', The Egyptian Journal of Hospital Medicine, 84(1), pp. 2411-2416. doi: 10.21608/ejhm.2021.184657
Shata, M., Shatla, H., Badawy, S., Metkees, M. Effects of Levetiracetam and Topiramate Monotherapy on Oral Health in Epileptic Children. The Egyptian Journal of Hospital Medicine, 2021; 84(1): 2411-2416. doi: 10.21608/ejhm.2021.184657
Effects of Levetiracetam and Topiramate Monotherapy on Oral Health in Epileptic Children
Background: Epilepsy is a common neurologic disease in children associated with multiple neurodevelopmental comorbidities or related to adverse drug reactions due to antiepileptic drugs. Objective: To study the effects of Levetiracetam (LEV) and Topiramate (TPM) monotherapy on oral cavity, to improve oral health care of epileptic children. Patients and methods: This study was conducted on 60 epileptic children of age group 6 -12 years compared to 30 normal age- and sex-matched controls, 30 children on LEV monotherapy and 30 on TPM monotherapy. All were subjected to full clinical dental examination by a pediatric dental expert. Results: There was significant increase in plaque index 50% grade 3 in children receiving antiepileptic medications, the decay-missing-filled (DMF) index was significantly more in children than in epileptic children, 43.3 % of children on antiepileptic having grade 1 Gingival index, while grade 2 gingival enlargements were noticed in 43.3% and dental hygiene was missed in 76.7% of children on antiepileptic drugs. Most of the indices were little more with TPM group than LEV group. Conclusions: Both LEV and TPM affect oral health of epileptic children, which makes regular screening for oral health by a pediatric dental expert necessary to detect early changes and intervene to improve their quality of life.
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