Effect of Aloe vera extract on some physiological parameters in diabetic albino rats.

Document Type : Original Article

Authors

1 Dept. of Zool., Fac. of Sci, Al-Azhar Univ.

2 Dept. of Phys., Fac. of Med., Menofeyah Univ.

3 Dept. of Zool., Fac. of Sci, Al-Azhar Univ

4 Dept. of Hist. Fac. of Med., Al-Azhar Univ .

Abstract

The present study aimed to clarify antidiabetic activity of aqueous extract from Aloe vera on thirty adult male albino rats were divided into three groups, the first served as a control group, the second was injected with alloxan (120mg / kg B.wt. ) and served as diabetic group and the third was injected with alloxan and treated with Aloe vera water extract ( 0.5 ml / 100 g B.wt. ). After thirty days of treatment half of each group were scarified and the other one were left for 15 days without any additional treatment as a recovery period .
The results revealed highly significant decrease ( p> 0.01) in blood glucose, and highly significant increase in both liver glycogen content and serum insulin level in the diabetic group treated with aqueos extract of A. vera when compared with the diabetic untreated group.
It seems, therefore that water extract of A. vera results in a definite hypoglycemic, hyperinsulinemic effect. On the other hand, a significant increase of body weight gain and liver glycogen content was achieved. The results of this study clarify the role of Aloe vera active as antidiabetic plant and suggest a relationship between drenching. A. vera extract and insulin production which needs further investigation .
 

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