Abd El Maksoud, A., . Abd Allah, A., Ismail, M., Massoud, W. (2004). Retinol and Alpha-Tocopherol Levels Among Hemodialysis Patients.. The Egyptian Journal of Hospital Medicine, 15(1), 65-71. doi: 10.21608/ejhm.2004.18187
Awatif M. Abd El Maksoud; Asmaa M . Abd Allah; Mervat A. Ismail; Waleed Massoud. "Retinol and Alpha-Tocopherol Levels Among Hemodialysis Patients.". The Egyptian Journal of Hospital Medicine, 15, 1, 2004, 65-71. doi: 10.21608/ejhm.2004.18187
Abd El Maksoud, A., . Abd Allah, A., Ismail, M., Massoud, W. (2004). 'Retinol and Alpha-Tocopherol Levels Among Hemodialysis Patients.', The Egyptian Journal of Hospital Medicine, 15(1), pp. 65-71. doi: 10.21608/ejhm.2004.18187
Abd El Maksoud, A., . Abd Allah, A., Ismail, M., Massoud, W. Retinol and Alpha-Tocopherol Levels Among Hemodialysis Patients.. The Egyptian Journal of Hospital Medicine, 2004; 15(1): 65-71. doi: 10.21608/ejhm.2004.18187
Retinol and Alpha-Tocopherol Levels Among Hemodialysis Patients.
1Clinical Nutrition Department, National Nutrition Institute.
2Nephrology Department ,Ahmed Maher Teaching Hospital.
Abstract
Plasma retinol, alpha tocopherol, total cholesterol and triglycerides were measured in 40 patients aged 27-65 years, under regular hemodialysis (HD) for 1.8-13 years at Ahmed Maher teaching Hospital and in 28 healthy age and sex matched control. Predialysis and postdialysis measurements were also, done for a subset of 13 hemodialytic patients. Among hemodialytic patients ,all values ( Plasma retinol ,alpha- tocopherol, total cholesterol and triglycerides )were significantly higher ( p < 0.05 ) with respect to healthy control .The ratio of retinol to total cholesterol was significantly higher , while alpha-tocopherol to total cholesterol ratio was insignificant .In almost all hemodialytic patients, plasma retinol was at toxic level (> 100 ug /dl) except for one patient . On the other hand ,alpha-tocopherol level in hemodialytic patients was ranged between deficiency (<650 ug/dl ) in about 6 (15%) of them , marginal level (650-860 ug/dl ) at 3 ( 8% ) , while 9 (23%) had normal level (860-1080ug/ dl) and the rest 22 (54% ) were in the optimum level (> 1080 ug/dl). Comparing predialysis and postdialysis measurements , the hemodialytic patients showed non significant difference concerning retinol level , while alpha tocopherol was significantly decreased in postdialytic state .In conclusion ; further studies are needed to answer, if hemodialytic patients are at risk for symptomatic vitamin A toxicity?. Even with normal or low plasma vitamin E, it is needed as an antioxidant accessory therapy in hemodialytic patients.
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