Possible Association Between the Chemokine Receptor Gene CCR5- Delta32 Mutation and Hepatitis C Virus Pathogenesis

Document Type : Original Article

Authors

1 Department of Medical Microbiology, Faculty of Medicine for Girls,

2 Department of Medical Virology School of Medicine, Kumamoto University, Japan;

3 Department of Medical Microbiology, Faculty of Medicine for Girls

4 Department of Internal Medicine, Theodore Bilharz Institute, Imbaba, Egypt

5 Department of Medical Virology School of Medicine, Kumamoto University, Japan

Abstract

Background: CCR5-Delta32, a 32-base pair deletion of the CC chemokine receptor (CCR)5 gene, is associated with slowed human immunodeficiency virus disease progression in heterozygotes and protection against infection in homozygotes between carriers and non-carriers of each genetic variant. The present study investigated the frequency and clinical consequence of the CCR%-Delta32 mutation in Egyptian HCV infected patients. Genomic DNA samples from 150 patients with chronic HCV infection were screened by PCR for the presence of the CCR5-Delta32 polymorphism. One hundred blood donors were used as control population. Results: The frequency of CCR5-Delta32 heterozygosity was 0.67% in chronic hepatitis C virus and 0% in controls. The CCR5-Delta32 allele was not associated with any of the clinical parameters of hepatitis C virus infection.
Conclusion: In this study, the frequency of CCR5-Delta32 homozygosity in patients with hepatitis C was similar to controls.
The Egyptian Journal of Hospital Medicine
Volume 17, Issue 1
October 2004
Pages 58-62

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