Effect Of Fractionated And Single Doses Gamma Irradiation On Certain Mammalian Organs

Abdel Motaal, Nabila A. R.; Abdel Maguid, Azza

doi:10.21608/ejhm.2005.18115

Effect Of Fractionated And Single Doses Gamma Irradiation On Certain Mammalian Organs

Document Type : Original Article

Authors

¹ Radiation Biology National Centre for Radiation Research and Technology, Cairo, Egypt.

² Radiation Health Research Departments, National Centre for Radiation Research and Technology, Cairo, Egypt.

10.21608/ejhm.2005.18115

Abstract

The present work aims to study the effect of fractionated and single dose whole body gamma irradiation on the liver, spleen and intestine of albino rats.
30 Male albino rats (100-120g) were used as experimental animals, they were divided into three groups: The first group consists of 10 rats served as control group (non irradiated), the second group (10 rats) were subjected to a single dose of irradiation (5Gy) and the third group (10 rats) were subjected to gamma of irradiation (5Gy) delivered at 5 successive exposures daily.
Histological results showed serious histopathological disorders in the liver, spleen and intestine after exposure to the single dose of gamma irradiation (5Gy), manifested by inflammation and infiltration with mononuclear cells, haemorrhage, dilatation, congestion and widening of blood vessels and necrosis of cells with pyknotic nuclei.
Exposure of rats to fractionated doses of whole body gamma irradiation (1Gy) up to 5Gy resulted in less severe histopathological disorders in liver, spleen and small intestine (jejunum),
This indicates the beneficial use of fractionated doses in planning for radiotherapy in cancer patients, thus reducing the serious histopathological changes of radiation on the human tissues.