The toxicity of tizanidine and baclofen was studied on male rats. The oral clinical dose of tizanidine and baclofen( 0.216 and o.54 mg/ 100g body weight / day, respectively)was given for one, two, three and four weeks. Chronic administration of the two drugs causes damage to the lung and a significant reduction in serum and lung levels of GSH , Vit E , Vit C and SOD activity . Four weeks treatment induced significant elevation of GPX activity and MDA levels. The two drugs, also, caused inhibitory activity on proliferation of splenocyte triggered by Con A, LPS and IL-2 production cell activities. They also produced several abnormal patterns in the EEG including increased epileptiform discharges and synchronous rhythmic activity . Diffuse slowing , with increased beta and delta activity and decreased alpha activity , with
superimposed beta activity were recorded. than baclofen .
El-Komey, F., EL-Gaafarawi, I., & Moustafa, H. (2005). Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.. The Egyptian Journal of Hospital Medicine, 20(1), 196-215. doi: 10.21608/ejhm.2005.18104
MLA
Fathy El-Komey; Inass EL-Gaafarawi; Hanan Moustafa. "Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.", The Egyptian Journal of Hospital Medicine, 20, 1, 2005, 196-215. doi: 10.21608/ejhm.2005.18104
HARVARD
El-Komey, F., EL-Gaafarawi, I., Moustafa, H. (2005). 'Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.', The Egyptian Journal of Hospital Medicine, 20(1), pp. 196-215. doi: 10.21608/ejhm.2005.18104
VANCOUVER
El-Komey, F., EL-Gaafarawi, I., Moustafa, H. Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.. The Egyptian Journal of Hospital Medicine, 2005; 20(1): 196-215. doi: 10.21608/ejhm.2005.18104
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