Interleukin-10, Interleukin- 16 and Interferon-γ in serum of patients with rheumatoid arthritis and correlation with disease activity

Document Type : Original Article

Authors

Clinical pathology& Internal Medicine Departments, Faculty of Medicine for girls, Al Azhar University

Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease of unknown etiology. The rheumatoid synovium is characterized by infiltration of T cells, macrophage, B cells, and proliferating fibroblasts which aggressively invade cartilage and bone, thus destroying joints' ability to function.
In rheumatoid arthritis (RA) both an imbalance between excessive production of the proinflamatory and ant-inflammatory cytokines and skewing of the T cell to a T helper like response.
Cytokines have been shown to play a modulatory role in the pathogenesis of RA. The imunoregulatory cytokine IL-10 increases autoantibody production by B cell stimulates its survival, proliferation and differentiation. Moreover IL-10 inhibits the generation of proinflamatory cytokines and proliferation of T helper lymphocyte.
Interleukin 16 might play a role in the pathogenesis of chronic inflammation in RA. It has a proinflammatory properties by promoting recruitment of T cells into the rheumatoid synovium. Also IFN-γ is of interest because of the role it plays in the initiation and perpetuation of T helper cell .
Serum level of IL-10, IL-16, and IFN-γ were determined in patients with rheumatoid arthritis in relation to disease activity.
All patients with RA (n=30) showed highly significant increase in ESR, CRP, IL-10, IL- 16, IFNγ compared to control group (p<0.01).
Positive correlation were found between IL-10 and each IL-16 and IFN-γ (p<0.001) (r=0.63, 0.55) respectively, and highly significant correlation between IL-16 and IFNγ (p<0.001) (r=0.89)were determined.
Results showed positive correlation between ESR and each IL-10, IL-16, IFNγ (p<0.001) (r=0.67, 0.87, 0.75) respectively. And highly significant correlation between CRP and each IL- 10, IL-16, IFNγ (p<0.001) (r=0.0.71, 0.83, 0.73) which indicate relation between increase level of cytokine with disease activity.
These data suggest that there is increased production of IL-10, IL-16, and IFN-γ in patients with rheumatoid arthritis, and that it is correlated with the disease activity. These




cytokines are interesting for further research inflammatory disease.

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