Helal, E., El-Kassas, M., Zaahkouk, S., Abdel-Wahed, H., Mahmoud, A. (2006). Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E.. The Egyptian Journal of Hospital Medicine, 22(1), 73-79. doi: 10.21608/ejhm.2006.18028
Eman G. E. Helal; Mahmoud A. El-Kassas; Samer A. M. Zaahkouk; Hesham G. Abdel-Wahed; Amany F. Mahmoud. "Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E.". The Egyptian Journal of Hospital Medicine, 22, 1, 2006, 73-79. doi: 10.21608/ejhm.2006.18028
Helal, E., El-Kassas, M., Zaahkouk, S., Abdel-Wahed, H., Mahmoud, A. (2006). 'Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E.', The Egyptian Journal of Hospital Medicine, 22(1), pp. 73-79. doi: 10.21608/ejhm.2006.18028
Helal, E., El-Kassas, M., Zaahkouk, S., Abdel-Wahed, H., Mahmoud, A. Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E.. The Egyptian Journal of Hospital Medicine, 2006; 22(1): 73-79. doi: 10.21608/ejhm.2006.18028
Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E.
1Departments of Zoology –Faculty of Science - Al-Azhar University(Girls)
2Faculty of Home Economics- jeddah, K.S.A.
Abstract
The current study aimed to clarify hazardous effect of ponceau 4R as food colour on rats and the effect of vitamin E as an antioxidant to prevent its toxic effect. Fourty premature growing male albino rats were divided into four groups, the first served as control group, the second supplemented with vitamin E (150 mg/kg),the third treated with ponceau 4R(0.19 mg/kg) and fourth treated with ponceau 4R(0.19 mg/kg) and vitamin E (150 mg/kg). Half of each group was treated for 3 m, the other half was treated for 6 months. Rats treated with ponceau 4R showed highly significant decrease (P<0.01) in serum total lipids, proteins, albumin levels and cholinesterase activity throughout the experimental period, while recorded a significant decrease (P<0.05) in glucose level till the end of the experiment and in globulin level and A/G ratio after 3 months of treatment only. On the other hand, significant increase was detected in total cholesterol level (P < .01) and AST activity (P < .05) after both periods of treatment, while ALT activity showed insignificant change. It seams from the presents study that vitamin E has protective effect against the side effect of ponceau 4R on rats.