Leptin Level and Plasma Prothrombotic Factors in Obese Subjects

Ezzat, Hamdia; Abd El-Rahman, )Eman M; Mousa, Sabilah G; Mahmoud, Eman A

doi:10.21608/ejhm.2006.18024

Leptin Level and Plasma Prothrombotic Factors in Obese Subjects

Document Type : Original Article

Authors

¹ Clinical Pathology Department, Al-Azhar and Assiut University

² Internal Medicine Department, Al-Azhar and Assiut University

³ Internal Medicine Departments, Al-Azhar and Assiut University

⁴ Rheumatology & Rehabilitation Departments, Al-Azhar and Assiut University

10.21608/ejhm.2006.18024

Abstract

Obesity is associated with increased cardiovascular morbidity and mortality. Abnormalities in coagulation and haemostasis represent a well-known link between obesity and thrombosis (both arterial and venous).
In human, production of a depocyte-derived peptide, leptin has been linked to adiposity; recent studies have shown that plasminogen activator inhibitor-1 (PAI-1),a prothrombotic factor associated with atherosclerosis complication is also produced in adipose tissue.
Several studies reported that obese subjects had elevated levels of vonWillbrand factor (vWF) and fibrinogen .
The aim of this work is to examine the relationship of obesity, fat distribution and serum leptin concentration with plasma levels of Prothrombotic factors (PAI-1 – (vWF) and fibrinogen) and lipid pattern (Triglycerides and Cholesterol) as metabolic parameters.
The body fat distribution was evaluated by measuring the body mass index ( BMI) and waist-to- hip ratio (WHR).