The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)

Waer, Hanaa F.; Edress, Saleh

doi:10.21608/ejhm.2006.17916

The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)

Document Type : Original Article

Authors

National Center for Radiation Research and Technology, Atomic Energy Authority Faculty of Medicine,Banha University

10.21608/ejhm.2006.17916

Abstract

Foodadditivesarechemicalsubstancesaddedintentionallytofoodstuffstopreserve, color,sweetenandflavorfood.Monosodiumglutamate(MSG)isusedasaflavorenhancerand foundinmostsoups,saladdressingandprocessedmeat.TheuseofMSGinfoodisgrowing. Irrationalfearhadincreasedinthelastfewyearsduetotheadversereactionsandtoxicityof MSG.
ThepresentstudywasdesignedtoinvestigatetheeffectofMSGontheratliverandthe amelioratingeffectoftaurineanalog“Guanidinoethanesulfonicacid(GES)”.Sixtyalbinorats (2-3monthsold)wereusedinthepresentstudy.MSGwasgivenorallyatadailydoseof60 mg/1000gforonemonth,twomonthsandwasgivenatadailydoseof100mg/1000gmforone month.TheresultsrevealedthatthedeleteriouseffectsofMSGweredoserelatedand cumulative.InMSGtreatedrats,theexaminedsectionsshowedremarkablealterationsvaried considerablyfrommoderatestructuralchangestocytoplasmiclysisandsignsofdegenerationof cellularorganelles.Thehistologicalchangesshoweddisturbedliverarchitecture,hemorrhagein thecentralveins,areasofnecrosis,vacuolationandincreasedinflammatorycellsinfiltration. Theglycogengranulesincreasedaswellasthecollagenfibersinthelivercells.Ultrastructural changesshowedlossofcytoplasmicdifferentiation,vacuolation,pyknoticnucleiwithirregular nuclearmembranesandelongatedelectrondensemitochondria.Conversely,treatmentofrats withtaurineanalog(GES)significantlyattenuatedthecellulartoxicityofMSG.