Background : Psoriasis is a common inflammatory skin disorder, has received attention as a target for new pathogenesis and oriented therapies . Autoimmunity and T lymphocyte subsets are suggested to be involved in the development of psoriasis. The aim of this work is to asses the role of T lymphocyte subsets in the pathogenesis of psoriasis . Material And Methods :We investigated the peripheral blood lymphocyte subpopulations obtained from psoriatic patient before and after treatment and from healthy controls, using two colour flow cytometry. Results :We found highly significant suppression of total CD3+ T Cells and CD3+ CD56+ NKT lymphocytes in psoriatic patient as compared to control. Also, we observed significant reduction of T helper cells in patients as compared to control. Conclusion : The highly significant reduction of CD3+ T cell and CD3+ CD56+ NKT lymphocytes proved their actively involvement in the development of psoriasis.
Darwish, H. M., Abd EL-Aziz, N. M., & EL-Marzouky, F. M. (2006). Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis. The Egyptian Journal of Hospital Medicine, 24(1), 477-483. doi: 10.21608/ejhm.2006.17910
MLA
Hanan M.A. Darwish; Nahla M. Abd EL-Aziz; Fatma M. EL-Marzouky. "Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis", The Egyptian Journal of Hospital Medicine, 24, 1, 2006, 477-483. doi: 10.21608/ejhm.2006.17910
HARVARD
Darwish, H. M., Abd EL-Aziz, N. M., EL-Marzouky, F. M. (2006). 'Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis', The Egyptian Journal of Hospital Medicine, 24(1), pp. 477-483. doi: 10.21608/ejhm.2006.17910
VANCOUVER
Darwish, H. M., Abd EL-Aziz, N. M., EL-Marzouky, F. M. Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis. The Egyptian Journal of Hospital Medicine, 2006; 24(1): 477-483. doi: 10.21608/ejhm.2006.17910
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