Non-fasting Non-High Density Lipoprotein Cholesterol (Non-HDL-C) AS A predictor of Atherosclerosis in Patients with End Stage Renal Disease on Regular Hemodialysis

Gohar, Sabry; Hosny, Mone; Abdel-Hamid, Howayda; Ibrahim, Yasser

doi:10.21608/ejhm.2006.17907

Non-fasting Non-High Density Lipoprotein Cholesterol (Non-HDL-C) AS A predictor of Atherosclerosis in Patients with End Stage Renal Disease on Regular Hemodialysis

Document Type : Original Article

Authors

¹ Internal Medicine Department, Ain Shams University

² Damanhour Medical Institute

10.21608/ejhm.2006.17907

Abstract

Fiftypatientswithchronicrenalfailureonregularhemodialysis31malesand19females, agedfrom18to62yearswereincludedinthestudy.Theywereselectedfromthoseattending theNephrologyandDialysisUnitinDamanhourMedicalInstitute.
Tenageandsexmatchedsubjectswithnormalrenalfunctionservedascontrolgroup.Full historytaking,clinicalexamination,restingECGandserumcholesterol,HDL(non-fasting), fastingLDL,non-fastingnon-HDLfromspecialequation,Non-HDL=totalcholesterol-HDL andDuplexscanningofbothcarotidandfemoralarteries.
Nonfastingnon-HDLwasmorethan130mg/dlinmorethan65%ofpatientsgroup versus30%incontrolgroup,serumlevelofnon-fastingcholesterolandnon-fastingnon-HDL weresignificantlyelevatedinhemodialysispatientsascomparedwithcontrolgroup,while serumlevelofnon-fastingHDLandfastingLDLweresignificantlydecreasedinhemodialysis patientsascomparedwithcontrolgroup.Intima-Mediathickness(IMT)ofbothcarotidsand bothfemoralarterieswaselevatedinhemodialysispatientsascomparedwithcontrolgroup. Therewasasignificantpositivecorrelationbetweennon-fastingnon-HDLandIMTofboth carotidsandbothfemoralarteriesandasignificantpositivecorrelationbetweenfastingLDL andIMTofbothcarotidsandfemoralarteries.Therewasasignificantpositivecorrelation betweendurationofdialysisandIMTofbothcarotidsandleftfemoralarteries.
ApositivecorrelationexistsbetweenECGischemicchangesandIMTofbothcarotidsand leftfemoralarteriesandbetweencarotidplaquesandIMTofbothcarotidsandleftfemoral arteries.
Aim of the Work
Tostudyandcomparebetweenthelevelofnon-fastingnon-HDL-CandfastingLDLin predialysisserumaspredictorofatheroscleroticchangesinpatientswithendstagerenaldisease onregularhemodialysis.