Effect of Bisphenol A on the Testis of Offspring of White Albino Rats during Pregnancy and Lactation: (Light and Electron Microscopic Study)

Abd Elhady, Al Sayed A.; Autifi, Mohamed A.; El Gizawy, Moustafa E.; Yousef, Moaaz M.

doi:10.21608/ejhm.2021.178609

Effect of Bisphenol A on the Testis of Offspring of White Albino Rats during Pregnancy and Lactation: (Light and Electron Microscopic Study)

Document Type : Original Article

Authors

10.21608/ejhm.2021.178609

Abstract

Introduction: The synthetic industrial and biomedical chemicals suspected to threat the health of the living organisms by disrupting their endocrine systems, referred to as endocrine disrupting chemicals (EDCs).
Objective: To study the effects of Bisphenol A (BPA) on the natal and postnatal testis by the light and electron microscope to make sure if it is harmful or not on the development of male reproductive organs in albino rats.
Matrial and Methods: Chemical used: Bisphenol A. The daily single oral dose was (0.3 mg/kg BW./day). Experimental animals: Adult female rats in proestrus cycle were caged overnight with adult males of proven fertility (1 male / 2 females / cage) and produced neonatal male rats.The offspring rats were divided into five main groups: Group I (Control offspring group), Group II (Experimental low dose treated offspring group with Bisphenol A (0.3 mg/kg BW./day) for two weeks, Group III (Experimental high dose treated offspring group; 12 mg/kg b.w/day), Group IV (First recovery group ), Group V (Second recovery group),
Results: Chronic Bisphenol A administration produced testicular toxicity leading to marked serious histological changes of the testis including the spermatogenic cells, spermatids, Sertoli cells and Leydig cells. These testicular changes increased with the high dose intake of BPA indicating its cumulative toxic effects that caused hypospermatogenesis, leading to infertility.
Conclusion: Bisphenol A administration causes testicular toxicity. So, these serious complications on testicular structure should be considered when buying any canned foods or drinks, because it is used nowadays on a large scale allover the world.

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