Effect Of Dietary Supplementation With Tigernut Tubers On Streptozotocin-Induced Diabetic Rats

Hassan, H. A.

doi:10.21608/ejhm.2007.17694

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The Egyptian Journal of Hospital Medicine

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	Effect Of Dietary Supplementation With Tigernut Tubers On Streptozotocin-Induced Diabetic Rats
Article 2, Volume 29, Issue 1, October 2007, Page 475-485 PDF (338.29 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2007.17694
View on SCiNiTO
Author
H. A. Hassan
Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.
Abstract
This work has been carried out to detect the effect of tigernut tubers as an antidiabetic plant on some biochemical parameters in streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by a single intraperitoneal injection of 45 mg STZ /kg body weight. The present results indicated an increase in both serum glucose level and liver glucose-6- phosphatase (G6P) activity in STZ-diabetic rats. In addition, a significant decrease in serum insulin level and liver glycogen content was recorded in the same rats. Moreover, serum total lipids, total cholesterol, triglycerides and LDL-cholesterol levels revealed a significant increase, while a decrease in the level of HDL-cholesterol was observed in STZ-diabetic rats. The activity of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) showed marked increase in STZ-diabetic rats. On the other hand, tigernut- supplemented diet (25% w/w) for two or four weeks recorded a significant improvement in all the above biochemical parameters affected by STZ injection especially after four weeks of treatment. Therefore, it was concluded that tigernut tubers had appreciable hypoglycemic and hypolipidemic effects on STZ-diabetic rats.
Keywords
Tigernut (Cyperus esculentus) – STZ-diabetic rats – lipid profiles


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