Electron Microscopic study of Desmosomes and Tonofilaments in Lichen Planus

Document Type : Original Article

Authors

1 Department of Dermatology and Venereology, Al- Azhar University for Girl, Cairo

2 Anatomy Department, Al- Azhar University for Boys, Cairo

Abstract

Introduction: Lichen planus (L.P) is an idiopathic inflammatory disease of the skin and mucous membrane.
Desmosomes are responsible for the adhesion of keratinocytes. Tonofilaments are one of the major cytoskeleton structure in mammalian epidermis.
Patients and Methods: Six patients complained from Lichen planus are included in this study for the study of ultrastructure of both desmosomes & tonofilaments .
Results: revealed an increase in the size and numbers of both of them which can be explained as a one of the defensive mechanism of the cells against frequent rubbing which is accompanied L.P. which is considered as a resistance mechanism of keratinocytes.