Omara, E., Nada, S., Zahran, H. (2009). Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride. The Egyptian Journal of Hospital Medicine, 35(1), 295-308. doi: 10.21608/ejhm.2009.17577
Enayat A. M. Omara; Somaia A. Nada; Hanan G. Zahran. "Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride". The Egyptian Journal of Hospital Medicine, 35, 1, 2009, 295-308. doi: 10.21608/ejhm.2009.17577
Omara, E., Nada, S., Zahran, H. (2009). 'Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride', The Egyptian Journal of Hospital Medicine, 35(1), pp. 295-308. doi: 10.21608/ejhm.2009.17577
Omara, E., Nada, S., Zahran, H. Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride. The Egyptian Journal of Hospital Medicine, 2009; 35(1): 295-308. doi: 10.21608/ejhm.2009.17577
Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride
1Pathology Dept National Research Centre, Dokki, Cairo, Egypt
2Pharmacology Dept National Research Centre, Dokki, Cairo, Egypt
3Clinical Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt
Abstract
Aim of the work: the present study was conducted to evaluate antioxidant, hepatoprotective, and immuno-stimulant properties of carotenes derived from food byproducts (tomato peels (TPW), mango peels (MP), corn gluten (CG), and agriculture dill waste (DW)), they were selected for their high superoxide dismutase activity (SOD). Material and methods: antioxidant and hepatoprotective effects were investigated in carbon tetrachloride (CCl4) damaged liver. Rats treated with oral doses of each carotene (25 mg /Kg b.wt.) for 15 days prior CCl4 administration and 4 days post- CCl4-treatment. Results: all tested carotenes significantly reduced the elevated values of liver function tests (GGT, ALT & AST) in hepatic damaged groups as well as, they had an immuno-stimulate property. They increased IgG levels in normal and liver damaged rats treated with the tested carotenoids. Whereas, IgG level reduced significantly by CCl4-tereatment. Histopathological examination of the liver tissues exposed to CCl4 showed inflammatory cell infiltration, necrosis and fibrosis. Glycogen and total protein contents also recorded. Treatments with carotenoids led to an improvement in the histological and histochemical alterations induced by CCl4. Conclusion, carotenes may play an important role as nutraceutical preparation, specially, when obtained from wastes of food byproducts in which economically of low coast production.
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