E.M, E., H.M, S., G.M, E. (2009). COMPARATIVE EFFECT BETWEEN CHITOSAN AND CHITOSAN- Cu COMPLEX ON CARBON-TETRACHLORIDE (CCL4) INDUCED LIVER DAMAGE IN RATS. The Egyptian Journal of Hospital Medicine, 36(1), 397-405. doi: 10.21608/ejhm.2009.17523
El-Habibi E.M; Sirag H.M; Edrees G.M. "COMPARATIVE EFFECT BETWEEN CHITOSAN AND CHITOSAN- Cu COMPLEX ON CARBON-TETRACHLORIDE (CCL4) INDUCED LIVER DAMAGE IN RATS". The Egyptian Journal of Hospital Medicine, 36, 1, 2009, 397-405. doi: 10.21608/ejhm.2009.17523
E.M, E., H.M, S., G.M, E. (2009). 'COMPARATIVE EFFECT BETWEEN CHITOSAN AND CHITOSAN- Cu COMPLEX ON CARBON-TETRACHLORIDE (CCL4) INDUCED LIVER DAMAGE IN RATS', The Egyptian Journal of Hospital Medicine, 36(1), pp. 397-405. doi: 10.21608/ejhm.2009.17523
E.M, E., H.M, S., G.M, E. COMPARATIVE EFFECT BETWEEN CHITOSAN AND CHITOSAN- Cu COMPLEX ON CARBON-TETRACHLORIDE (CCL4) INDUCED LIVER DAMAGE IN RATS. The Egyptian Journal of Hospital Medicine, 2009; 36(1): 397-405. doi: 10.21608/ejhm.2009.17523
COMPARATIVE EFFECT BETWEEN CHITOSAN AND CHITOSAN- Cu COMPLEX ON CARBON-TETRACHLORIDE (CCL4) INDUCED LIVER DAMAGE IN RATS
Zoology Dept., Faculty of Science, Mansoura University, Mansoura, Egypt
Abstract
BACKGROUND: Carbon tetrachloride (CCl4 ) is a toxic material known to induce lipid peroxidation and liver damage.
The possible protective roles that involved by chitosan or chitosan-Cu complex against CCl4 induced liver intoxication were investigated in male rats. RESULTS: CCl4 administred at dose 20 mg/kg body weight i.p., exceed malondialdehyde (MDA) and protein carbonyle (PC), depleted superoxide dismutase (SOD) and glutathione (GSH), in concomitant with marked increase in investigated liver function parameters , alanine aminotransferase and aspartate aminotransferase (ALT, AST), impaired serum and liver total protein , albumin and globulin. An elevation in serum and hepatic total lipids, total cholesterol, triglycerides and serum LDL and VLDL levels as well as a low level of HDL were recorded. In the same time, there was a significant increase in sodium and iron contents in the serum while a significant decrease in potassium and zinc contents were recorded.
Animals pretreated with chitosan (200 mg /kg body weight) orally by stomach tube for 21 consecutive days prior to CCl4 challenge significantly attenuated most of the tested parameters, strengthen antioxidant defense system, ameliorated liver function effectively. Chitosan-Cu complex has a protective effect by a higher degree than that of chitosan only. CONCLUSION: These findings suggest that pretreatment with chitosan-Cu complex has higher hepato-protective effects than that of only chitosan against CCl4 induced toxicity in rat.
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