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baz, E., Eldin, T. (2010). Endothelial nitric oxide synthase gene polymorphisms (G894T) in diabetes mellitus in Egypt. The Egyptian Journal of Hospital Medicine, 38(1), 82-93. doi: 10.21608/ejhm.2010.17372
El baz; Tag Eldin. "Endothelial nitric oxide synthase gene polymorphisms (G894T) in diabetes mellitus in Egypt". The Egyptian Journal of Hospital Medicine, 38, 1, 2010, 82-93. doi: 10.21608/ejhm.2010.17372
baz, E., Eldin, T. (2010). 'Endothelial nitric oxide synthase gene polymorphisms (G894T) in diabetes mellitus in Egypt', The Egyptian Journal of Hospital Medicine, 38(1), pp. 82-93. doi: 10.21608/ejhm.2010.17372
baz, E., Eldin, T. Endothelial nitric oxide synthase gene polymorphisms (G894T) in diabetes mellitus in Egypt. The Egyptian Journal of Hospital Medicine, 2010; 38(1): 82-93. doi: 10.21608/ejhm.2010.17372

Endothelial nitric oxide synthase gene polymorphisms (G894T) in diabetes mellitus in Egypt

Article 7, Volume 38, Issue 1, January 2010, Page 82-93  XML PDF (352.07 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2010.17372
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Authors
El baz1; Tag Eldin2
1Genetics Unit, Mansoura University
2Research Institute (GEBRI),Sadat City
Abstract
Objective: Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes. Genetic predisposition has been implicated in DN. The eNOS protein synthesizes nitric oxide constitutively via a  reaction including the conversion of L-arginine to L-citrulline, which involves the transfer of five electrons provided by nicotinamide adenine dinucleotide phosphate The aim of this study is to evaluate the association of G894T polymorphisms of endothelial nitric oxide synthase(eNOS) gene with the development of diabetic nephropathy (DN) among Egyptian patients with type 1,2 diabetes mellitus  in Egypt. Methods: Study subjects comprised 86 patients of type 2 diabetes with nephropathy,23 patients of type 1 diabetes with nephropathy and 46 patients of type 2 diabetes without nephropathy. G894T genotypes was determined by SSP- PCR analysis. Results: Mutant T allele, GT and TT genotypes of G894TSNP had no significant frequencies in type 1,2 diabetic patients with nephropathy compared to those without nephropathy.. Conclusion: These findings indicate that G894T polymorphism of eNOS gene may be not considered as genetic risk factors for DN among Egyptian type1, 2 diabetic patients.
Abbreviations: T2DM: type 2 diabetes mellitus – DN: diabetic nephropathy eNOS : Endothelial nitric oxide synthase:– SNP: single nucleotide polymorphism- SSP-PCR: sequence specific primer- polymerase chain reaction.
 
 
Keywords
eNOS gene – Type1; 2 diabetes - diabetic nephropathy
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