Rizk, M., Hussein, A., Afifi, M., Ameen, S., Ahmed Ragab, E. (2021). Pancreatic Exocrine Insufficiency among Diabetic Patients. The Egyptian Journal of Hospital Medicine, 83(1), 1490-1495. doi: 10.21608/ejhm.2021.170512
Mahmoud Rizk; Ahmed Mohamed Hussein; Mohamed Abd Ellatif Afifi; Seham Gouda Ameen; El-Gazzarah Ahmed Ragab. "Pancreatic Exocrine Insufficiency among Diabetic Patients". The Egyptian Journal of Hospital Medicine, 83, 1, 2021, 1490-1495. doi: 10.21608/ejhm.2021.170512
Rizk, M., Hussein, A., Afifi, M., Ameen, S., Ahmed Ragab, E. (2021). 'Pancreatic Exocrine Insufficiency among Diabetic Patients', The Egyptian Journal of Hospital Medicine, 83(1), pp. 1490-1495. doi: 10.21608/ejhm.2021.170512
Rizk, M., Hussein, A., Afifi, M., Ameen, S., Ahmed Ragab, E. Pancreatic Exocrine Insufficiency among Diabetic Patients. The Egyptian Journal of Hospital Medicine, 2021; 83(1): 1490-1495. doi: 10.21608/ejhm.2021.170512
Pancreatic Exocrine Insufficiency among Diabetic Patients
1Internal Medicine Department, Gastroenterology and hepatology unit, Faculty of Medicine, Benha University, Egypt
2Departments of Internal Medicine Faculty of Medicine, Benha University, Egypt
3Departments of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt
4Department of Tropical Medicine, Faculty of Medicine, Menoufia University, Egypt
Abstract
Background: Various studies have defined the existence of pancreatic exocrine insufficiency (PEI) in diabetic patients. The concentration of faecal elastase-1 (FE-1) has long been used as a screening method for exocrine pancreatic activity, with good results when compared to direct methods. The prevalence of pancreatic exocrine insufficiency in Egyptian diabetic patients measured by FE-1 concentration is still unknown. Objective: To investigate the prevalence of PEI in Egyptian diabetic patients, and to examine its relationship with the degree of glycemic control and other metabolic parameters. Patients and Methods: In this cross-sectional study, 180 diabetic patients, were divided into two equal groups. Group I: patients with type 1 diabetes mellitus (T1D) and Group II: patients with type 2 diabetes mellitus (T2D). Other 90 healthy subjects were enrolled in the study as a control group (Group III). All participants were evaluated for PEI by measuring the FE-1 concentration through the enzyme-linked immunosorbent assay (ELISA) method. Patients having FE-1 concentration < 200 µg/g of stool were diagnosed with PEI. Results: The prevalence of PEI was 35.6% in T1D, 31.3% in T2D, and 7.8% in the control group (P < 0.001). A significant negative correlation was observed between FE-1 levels and both FBS and HbA1c in diabetic patients. There was also a significant positive correlation between body mass index (BMI) and FE-1 concentration for T1D and T2D groups. Conclusion: Significant PEI was observed in Egyptian T1D and T2D patients assessed by the FE-1 concentration test.
View on SCiNiTO
Top