Al-Barshomy, S., Allam, H., Tantawi, H. (2021). Relationship Between Serum Adipocyte Fatty Acid Binding Protein and Atherosclerosis in Type 2 Diabetes Patients. The Egyptian Journal of Hospital Medicine, 83(1), 1484-1489. doi: 10.21608/ejhm.2021.170511
said M Al-Barshomy; Hala Allam; Hazem Tantawi. "Relationship Between Serum Adipocyte Fatty Acid Binding Protein and Atherosclerosis in Type 2 Diabetes Patients". The Egyptian Journal of Hospital Medicine, 83, 1, 2021, 1484-1489. doi: 10.21608/ejhm.2021.170511
Al-Barshomy, S., Allam, H., Tantawi, H. (2021). 'Relationship Between Serum Adipocyte Fatty Acid Binding Protein and Atherosclerosis in Type 2 Diabetes Patients', The Egyptian Journal of Hospital Medicine, 83(1), pp. 1484-1489. doi: 10.21608/ejhm.2021.170511
Al-Barshomy, S., Allam, H., Tantawi, H. Relationship Between Serum Adipocyte Fatty Acid Binding Protein and Atherosclerosis in Type 2 Diabetes Patients. The Egyptian Journal of Hospital Medicine, 2021; 83(1): 1484-1489. doi: 10.21608/ejhm.2021.170511
Relationship Between Serum Adipocyte Fatty Acid Binding Protein and Atherosclerosis in Type 2 Diabetes Patients
2Departments of 1Internal Medicine and Nephrology Faculty of Medicine, Zagazig University, Egypt
3Departments of Internal Medicine and Nephrology Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: Atherosclerosis as a complication of diabetes, is considered to be a chronic inflammatory disease, developing over years and proceeding through many steps. Adiposity fatty acid–binding protein (A-FABP) is highly expressed in mature adipocytes and plays a central regulatory role in energy metabolism and inflammation. A-FABP mRNA expression in adipose tissues predicted coronary artery disease in homozygous subjects. A-FABP may also play a role in the development of atherosclerotic diseases in humans. Objective: To detect the relationship between serum A-FABP level and carotid intima-media thickness (IMT) as indicator of atherosclerosis in patients with type 2 diabetes mellitus. Patients and methods: 124 patients with type 2 diabetes (T2D), were divided into two groups: Group 1: 62 patients with T2D ≤ 5 years duration, and Group 2: 62 patients with T2D > 5 years duration. They were subjected to full history taking, clinical examination, and laboratory investigations in the form of CBC, LFT, KFT, HBA1c, fasting and postprandial blood sugar, A-FABP serum level, and carotid Doppler. Results: Serum level A-FABP and carotid IMT was significantly higher in long standing diabetes group compared to short standing diabetes group.A-FABP cutoff was proven to have a high sensitivity 94.4%, specificity 100.0%, positive predictive value of 100.0%, negative predictive value of 97.7% and overall accuracy of 98.3% regarding the prediction of atherosclerosis. Conclusions: A-FABP serum level have a high sensitivity, specificity, predictive value and overall accuracy regarding atherosclerosis, and should be recommended as a part of routine surveillance for atherosclerosis in patients with type 2 diabetes.
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